Tinea infections:
Tinea corporis/tinea cruris: Topical: Cream, lotion: Apply to affected and surrounding area(s) 1 to 2 times daily until clinical resolution, typically 1 to 3 weeks (Goldstein 2021; van Zuuren 2015; Weinstein 2002; manufacturer’s labeling).
Tinea pedis (labeled use)/tinea manuum (off-label use): Topical: Cream, lotion: Apply to affected and surrounding area(s) 1 to 2 times daily until 1 week after clinical resolution, typically for 4 weeks total (Goldstein 2021; Weinstein 2002; manufacturer’s labeling).
Tinea versicolor: Topical: Cream: Apply to affected areas once daily for 2 weeks.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
Tinea corporis, tinea cruris, tinea pedis, tinea versicolor: Children ≥12 years and Adolescents: Topical: Cream: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External:
Oxistat: 1% (30 g, 60 g, 90 g) [contains benzoic acid, cetyl alcohol, propylene glycol]
Generic: 1% (30 g, 60 g, 90 g)
Lotion, External:
Oxistat: 1% (30 mL, 60 mL) [contains benzoic acid, cetyl alcohol, propylene glycol]
May be product dependent
For external use only; avoid contact with eyes, nose, mouth, or other mucous membranes. Avoid occlusive dressings. Wash hands before and after use.
Topical: For external use only; avoid contact with eyes, nose, mouth, or other mucous membranes. Apply to the affected area(s) and the immediate surrounding tissue. Avoid occlusive dressings unless otherwise directed. Wash hands before and after use.
Cream: Topical treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum; and tinea (pityriasis) versicolor due to Malassezia furfur
Lotion: Treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum
Tinea manuum
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%:
Central nervous system: Localized burning (≤1%)
Dermatologic: Pruritus (<2%)
<1%, postmarketing, and/or case reports: Allergic contact dermatitis, dyshidrotic eczema, erythema, exfoliation of skin, folliculitis, maceration of the skin, nodule, pain, papule, skin fissure, skin irritation, skin rash, stinging of the skin, tingling of skin
Hypersensitivity to oxiconazole or any component of the formulation
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs
Other warnings/precautions:
• Appropriate use: For topical use only; not for ophthalmologic, oral, or vaginal use.
None known.
There are no known significant interactions.
When administered orally, teratogenic effects were not observed in animal reproduction studies.
Systemic absorption is low, however, the manufacturer reports that oxiconazole is excreted in breast milk.
The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Microsporum canis, Microsporum audouinii, Microsporum gypseum, Epidermophyton floccosum, Candida albicans, and Malassezia furfur.
Absorption: In each layer of the dermis; very little systemically after one topical dose
Distribution: To each layer of the dermis
Excretion: Urine (<0.3%)
Cream (Oxiconazole Nitrate External)
1% (per gram): $10.40
Cream (Oxistat External)
1% (per gram): $13.05
Lotion (Oxistat External)
1% (per mL): $25.73
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