Fungal blepharitis or conjunctivitis: Ophthalmic: Instill 1 drop in conjunctival sac 4 to 6 times daily.
Fungal keratitis: Ophthalmic: Instill 1 drop in conjunctival sac every 1 to 2 hours, after 3 to 4 days reduce to one drop 6 to 8 times daily; usual course of therapy is 2 to 3 weeks or until resolution of active fungal keratitis (may be useful to gradually reduce dosage at 4- to 7-day intervals to assure elimination of organism).
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Suspension, Ophthalmic:
Natacyn: 5% (15 mL [DSC])
Natacyn: 5% (15 mL) [contains benzalkonium chloride]
No
Ophthalmic: For topical ophthalmic use only. Shake well before using. Wash hands before and after use. Do not touch tip of applicator to eye or other surfaces.
Ocular fungal infections: Treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms, including Fusarium solani keratitis.
Natacyn may be confused with Naprosyn
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Postmarketing and/or case reports: Allergic reaction, chest pain, corneal opacity, dyspnea, eye discomfort, edema, hyperemia, irritation and/or pain, foreign body sensation, parasthesia, tearing, vision changes
Hypersensitivity to natamycin or any component of the formulation
Disease-related concerns:
• Epithelial ulceration: Suspension may adhere to epithelial ulcers; retention of the suspension in the fornices occurs regularly.
Special populations:
• Contact lens wearers: Contains benzalkonium chloride, which may be absorbed by soft contact lenses; remove lenses prior to administration. Contact lenses should not be worn during treatment of ophthalmologic infections (including fungal blepharitis, conjunctivitis, and keratitis).
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only. Failure to improve (keratitis) after 7 to 10 days of administration suggests infection caused by a microorganism not susceptible to natamycin; efficacy as a single agent in fungal endophthalmitis has not been established.
None known.
There are no known significant interactions.
Animal reproduction studies have not been conducted.
It is not known if natamycin is excreted in breast milk. The manufacturer recommends that caution be exercised when administering natamycin to nursing women.
Binds to sterol in fungal cell membrane and changes the cell wall permeability allowing for a reduction of cellular contents
Absorption: Ophthalmic: Systemic, not expected; Gastrointestinal: Poor
Distribution: Adheres to cornea, retained in conjunctival fornices; does not produce effective intraocular fluid concentrations
Suspension (Natacyn Ophthalmic)
5% (per mL): $37.89
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