Conjunctivitis and keratitis: Ophthalmic: Instill 1 to 2 drops in each eye 4 to 6 times daily. Symptomatic response is often evident within a few days; continue therapy as long as required.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
(For additional information see "Cromolyn (sodium cromoglicate) (ophthalmic): Pediatric drug information")
Conjunctivitis and keratitis: Children ≥4 years and Adolescents: Ophthalmic: Instill 1 to 2 drops in each eye 4 to 6 times daily at regular intervals
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic, as sodium:
Generic: 4% (10 mL)
Yes
For ophthalmic use only. Wash hands prior to use. Instill drops inside the lower eyelid; avoid instilling directly on the cornea. To avoid contamination, do not touch dropper tip to eye, eyelid, fingers, or any other surface. Do not wear contact lenses during treatment.
For ophthalmic use. Wash hands prior to use. Instill into conjunctival sac avoiding contact of bottle tip with skin or eye. Apply gentle pressure to lacrimal sac during and immediately following instillation (1 minute) or instruct patient to gently close eyelid after administration, to decrease systemic absorption of ophthalmic drops (Urtti 1993; Zimmerman 1982). Patients should not wear contact lenses during treatment.
Conjunctivitis/keratitis: Treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
Ocular: Conjunctival injection, dryness around the eye, edema, eye irritation, immediate hypersensitivity reactions, itchy eyes, puffy eyes, styes, rash, watery eyes
Respiratory: Dyspnea
Hypersensitivity to cromolyn or any component of the formulation
Concerns related to adverse effects:
• Irritation: May cause transient burning or stinging upon instillation.
Special populations:
• Contact lens wearers: Some products may contain benzalkonium chloride which may be absorbed by contact lenses; do not wear contact lenses during treatment.
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only; not for injection. To avoid contamination, do not touch dropper tip to eye, eyelid, fingers, or any other surface when placing drops in eyes.
None known.
There are no known significant interactions.
Adverse events have not been observed in animal reproduction studies following SubQ administration. Systemic absorption following ophthalmic application is limited (~0.03%).
It is not known if cromolyn is excreted in breast milk. Systemic absorption following ophthalmic application is limited (~0.03%). The manufacturer recommends that caution be exercised when administering cromolyn to breastfeeding women.
Mast cell stabilizer that inhibits the in vivo and in vivo release of histamine and slow-reacting substance of anaphylaxis (SRS-A) associated with antigen-mediated reactions.
Onset of action: Response to treatment: May be seen within a few days; treatment for up to 6 weeks is often required
Absorption: ~0.03%
Solution (Cromolyn Sodium Ophthalmic)
4% (per mL): $3.72 - $3.73
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