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Cetylpyridinium: Drug information

Cetylpyridinium: Drug information
(For additional information see "Cetylpyridinium: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Antiseptic Oral Rinse [OTC] [DSC];
  • Cepacol Antibacterial [OTC];
  • Clean Zing [OTC] [DSC];
  • GoodSense Oral Rinse [OTC];
  • Larynex [OTC] [DSC]
Pharmacologic Category
  • Antiseptic, Oral Mouthwash
Dosing: Adult

Antiseptic (OTC labeling): Oral: Swish 20 mL thoroughly between teeth for 30 seconds then spit; use twice daily; may be used before or after brushing; do not swallow.

Dosing: Pediatric

Antiseptic (OTC labeling): Children ≥6 years: Refer to adult dosing.

Dosing: Older Adult

Refer to adult dosing.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Liquid, Mouth/Throat, as chloride:

Antiseptic Oral Rinse: 0.05% (44 mL [DSC]) [alcohol free; contains brilliant blue fcf (fd&c blue #1), polysorbate 80]

Cepacol Antibacterial: 0.05% (710 mL) [contains alcohol, usp, edetate (edta) disodium, menthol, polysorbate 80, saccharin sodium, tartrazine (fd&c yellow #5)]

Clean Zing: 0.06% (480 mL [DSC]) [alcohol free, no artificial color(s); contains sodium benzoate]

GoodSense Oral Rinse: 0.07% (1000 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, propylene glycol, propylparaben, saccharin sodium]

Lozenge, Mouth/Throat, as chloride:

Larynex: (500 ea [DSC])

Generic Equivalent Available: US

Yes

Administration: Adult

Vigorously swish between teeth; do not swallow.

Administration: Pediatric

Oral: Vigorously swish between teeth; do not swallow. Supervise use in children 6 to <12 years of age.

Use: Labeled Indications

Antiseptic to aid in the prevention and reduction of plaque and gingivitis, and to freshen breath

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined. Gastrointestinal: Dental discoloration, mouth irritation, tongue discoloration

Contraindications

Hypersensitivity to cetylpyridinium or any component of the formulation

Warnings/Precautions

Other warnings/precautions:

• Accidental ingestion: If an amount greater than used for rinsing is swallowed, seek professional assistance or contact a poison control center immediately.

• Self-medication (OTC use): Stop use and consult a healthcare professional if symptoms or condition worsening or persists; if gingivitis, bleeding, or redness persists for more than 2 weeks; if gums are painful and swollen; if pus from the gum line, loose teeth, or increased spacing between the teeth occurs. Avoid contact with eyes.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Cetylpyridinium chloride mouthwash (alcohol free) has been associated with a reduction in preterm births in pregnant women with periodontal disease (Jeffcoat, 2011).

Pricing: US

Liquid (Cepacol Antibacterial Mouth/Throat)

0.05% (per mL): $0.01

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Brand Names: International
  • Ai Nuo Tian Jian (CN);
  • Algol (IT);
  • Alsol (IT);
  • Angifonil (ES);
  • B-Fresh (EG);
  • Bat Zeta (IT);
  • Ben Li (CN);
  • Borocaina (IT);
  • Bronchenolo Gola (IT);
  • Cepacol (AU, BR, CO, HK, NZ, SG, TH, VE, ZA);
  • Cetilsan (IT);
  • Cetosept (EG);
  • Claragine (CL);
  • Cleanthroat (TW);
  • Coolstrip Film Troche (KR);
  • Curisol (ES);
  • Farin Gola (IT);
  • Freesept (CL);
  • Geyderm Sepsi (IT);
  • Golacetin (IT);
  • Halset (AT, CH, CZ, HU, PL);
  • Herbagola (IT);
  • Menthosept (PL);
  • Merocet (AE);
  • Merocets (GB, IE, MT);
  • Neo Cepacol (IT);
  • Neo Coricidin (IT);
  • Neo Formitrol (IT);
  • Novoptine (CH, FR);
  • Orasept (TH);
  • Pronto G (IT);
  • Pyrisept (NO);
  • Septolete Neo (RU);
  • Tirocetil (ES)


For country abbreviations used in Lexicomp (show table)

REFERENCES

  1. Jeffcoat M, Parry S, Gerlach RW, et al, "Use of Alcohol-Free Antimicrobial Mouth Rinse Is Associated With Decreased Incidence of Preterm Birth in a High-Risk Population," Am J Obstet Gynecol, 2011, 205(4):382.e1-6. [PubMed 22083060]
  2. Cepacol Antibacterial (cetylpyridinium chloride) [prescribing information]. Parsippany, NJ: Reckitt Benckiser; received May 2020.
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