Allergic conjunctivitis: Ophthalmic: Instill 1 drop into each eye twice daily. Continue throughout period of exposure, even in the absence of symptoms.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
(For additional information see "Epinastine: Pediatric drug information")
Allergic conjunctivitis: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into each eye twice daily; continue throughout period of exposure, even in the absence of symptoms
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely necessary due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely necessary due to low systemic absorption.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Ophthalmic, as hydrochloride:
Elestat: 0.05% (5 mL [DSC]) [contains benzalkonium chloride]
Generic: 0.05% (5 mL)
Yes
For ophthalmic use only; avoid touching tip of applicator to eye or other surfaces. Contact lenses should be removed prior to application, may be reinserted after 10 minutes. Do not wear contact lenses if eyes are red.
For ophthalmic use only; avoid touching tip of applicator to eye or other surfaces. Contact lenses should be removed prior to application; may be reinserted after 10 minutes. Do not wear contact lenses if eyes are red.
Allergic conjunctivitis: Prevention of itching of the eye associated with allergic conjunctivitis.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not always defined.
1% to 10%:
Central nervous system: Headache (1% to 3%)
Infection: Infection (10%; defined as cold symptoms and upper respiratory tract infection)
Ophthalmic: Burning sensation of eyes, eye pruritus, follicular conjunctivitis, ocular hyperemia
Respiratory: Cough (1% to 3%), pharyngitis (1% to 3%), rhinitis (1% to 3%), sinusitis (1% to 3%)
<1%, postmarketing, and/or case reports: Increased lacrimation
There are no contraindications listed in the manufacturer's labeling.
Concerns related to adverse effects:
• Bacterial keratitis: Inadvertent contamination of multiple-dose ophthalmic solutions has caused bacterial keratitis.
Special populations:
• Contact lens wearers: Contains benzalkonium chloride which may be absorbed by contact lenses; remove contact lenses prior to use and wait 10 minutes before reinserting.
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only. Not for the treatment of contact lens irritation; do not wear contact lenses if eye is red.
None known.
There are no known significant interactions.
Adverse events were observed in some animal reproduction studies.
It is not known if epinastine is excreted in breast milk. The manufacturer recommends that caution be exercised when administering epinastine to nursing women.
Selective H1-receptor antagonist; inhibits release of histamine from the mast cell; also has affinity for the H2, alpha1, alpha2, and the 5-HT2 receptors
Onset of action: 3 to 5 minutes.
Duration: 8 hours.
Absorption: Low systemic absorption following topical application.
Distribution: Does not cross blood-brain barrier.
Protein binding: 64%.
Metabolism: <10% metabolized.
Half-life elimination: Terminal: ~12 hours.
Excretion: IV: Urine (~55% as unchanged drug); feces (~30%).
Solution (Epinastine HCl Ophthalmic)
0.05% (per mL): $20.52 - $21.40
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