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Wheat dextrin: Drug information

Wheat dextrin: Drug information
(For additional information see "Wheat dextrin: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Benefiber Drink Mix [OTC];
  • Benefiber For Children [OTC];
  • Benefiber Plus B Vits & FA [OTC];
  • Benefiber Plus Calcium [OTC];
  • Benefiber Plus Heart Health [OTC];
  • Benefiber [OTC]
Pharmacologic Category
  • Fiber Supplement;
  • Laxative, Bulk-Producing
Dosing: Adult

General dosing guidelines; consult specific product labeling.

Dietary fiber supplement: Benefiber: Oral: 4 grams (2 teaspoons) added to 4 to 8 ounces of liquid or soft food 3 times daily

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Pediatric

(For additional information see "Wheat dextrin: Pediatric drug information")

Constipation, occasional and abdominal discomfort:

Powder (bulk) (Benefiber Advanced Digestive Health):

Children 6 to <12 years: Oral: 1 tablespoon (4 g fiber/dose) once daily.

Children ≥12 years and Adolescents: Oral: 1 tablespoon (4 g fiber/dose) twice daily.

Dietary fiber supplement:

Chewable tablets (Benefiber Chewables):

Children 6 to <12 years: Oral: 11/2 tablets (4 g fiber/dose) 1 to 3 times daily; maximum daily dose: 41/2 tablets/day.

Children ≥12 years and Adolescents: Oral: 3 tablets (6 g fiber/dose) 1 to 3 times daily; maximum daily dose: 9 tablets/day.

Powder (bulk) (Benefiber Prebiotic Fiber Supplement):

Children 6 to <12 years: Oral: 1 teaspoon (2 g fiber/dose) added to 4 to 8 ounces of liquid or soft food 3 times daily.

Children ≥12 years and Adolescents: Oral: 2 teaspoons (3 g fiber/dose) added to 4 to 8 ounces of liquid or soft food 3 times daily.

Powder (individual packets) (Benefiber on the GO):

Children 6 to <12 years: Oral: 1/2 packet (2 g fiber/dose) added to 4 to 8 ounces of liquid or soft food 3 times daily.

Children ≥12 years and Adolescents: Oral: 1 packet (3 g fiber/dose) added to 4 to 8 ounces of liquid or soft food 3 times daily.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Packet, Oral:

Benefiber Drink Mix: (28 ea) [flavor free, gluten free, grit free, sugar free]

Benefiber Drink Mix: (8 ea) [sugar free; contains aspartame; raspberry tea flavor]

Benefiber Drink Mix: (8 ea, 24 ea) [sugar free; contains aspartame, fd&c red #40; cherry pomegranate flavor]

Benefiber Drink Mix: (16 ea, 24 ea) [sugar free; contains aspartame, fd&c red #40; kiwi strawberry flavor]

Benefiber Drink Mix: (16 ea) [sugar free; contains aspartame, fd&c yellow #6 (sunset yellow), soybean oil, tartrazine (fd&c yellow #5); citrus punch flavor]

Powder, Oral:

Benefiber: (80 g, 155 g, 245 g, 350 g, 477 g, 730 g) [gluten free, grit free, sugar free]

Benefiber: (267 g, 529 g) [grit free, sugar free; contains aspartame, fd&c red #40, fd&c yellow #6 (sunset yellow), lactose; orange flavor]

Benefiber For Children: (155 g) [grit free, sugar free; unflavored flavor]

Benefiber Plus Calcium: (423.8 g) [gluten free, grit free, sugar free]

Benefiber Plus Calcium: (305 g) [gluten free, grit free, sugar free; contains aspartame, fd&c red #40, fd&c yellow #6 (sunset yellow); orange flavor]

Benefiber Plus Heart Health: (182.4 g) [gluten free, grit free, sugar free; contains sodium benzoate]

Tablet, Oral:

Benefiber Plus B Vits & FA: [contains sodium benzoate]

Tablet Chewable, Oral:

Benefiber Plus Calcium: [scored; sugar free; contains aspartame, fd&c blue #1 aluminum lake, fd&c red #40 aluminum lake, soybeans (glycine max); wild berry flavor]

Generic Equivalent Available: US

No

Administration: Adult

Oral: Powder can be mixed into hot or cold beverages (eg, water, coffee, juice), soft foods (eg, applesauce, pudding, yogurt), or cooked into recipes for foods; not recommended for use in carbonated beverages. Tablets should be swallowed with liquid.

Administration: Pediatric

Oral:

Chewable tablet: Chew thoroughly.

Powder: Mix powder into 4 to 8 ounces of hot or cold beverages (eg, water, coffee, juice); mix until dissolved (~1 minute); may also mix in soft foods (eg, applesauce, pudding, yogurt), or added into recipes; not recommended for use in carbonated beverages.

Use: Labeled Indications

Dietary fiber supplement: Use as a dietary fiber supplement

Use: Off-Label: Adult

Constipation

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined: Gastrointestinal: Bloating, flatulence, gastrointestinal distress

Warnings/Precautions

Disease-related concerns:

• Coronary heart disease (CHD): To aid in reducing the risk of CHD, the soluble fiber from wheat dextrin should be used in conjunction with a diet low in saturated fat and cholesterol.

• Gastrointestinal disease: Use with caution in patients with esophageal strictures, ulcers, stenosis, or intestinal adhesions, GI obstruction, fecal impaction, or difficulty swallowing.

Dosage form specific issues:

• Aspartame: Some products may contain aspartame.

• Calcium: Some products may contain calcium.

• Phenylalanine: Some products may contain phenylalanine.

• Potassium: Some products may contain potassium.

• Sodium: Some products may contain sodium.

Special populations:

• Elderly: Use with caution in the elderly; may have insufficient fluid intake which may predispose them to fecal impaction and bowel obstruction.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Dietary Considerations

Some products may contain phenylalanine, potassium, and/or sodium, as well as additional ingredients. Check individual product information for caloric and nutritional value.

Adequate intake for total fiber: Oral: Note: The definition of “fiber” varies; however, the soluble fiber in wheat dextrin is only one type of fiber which makes up the daily recommended intake of total fiber.

1 to 3 years: 19 g/day

4 to 8 years: 25 g/day

9 to 13 years: Males: 31 g/day; Females: 26 g/day

14 to 18 years: Males: 38 g/day; Females: 26 g/day

19 to 50 years: Males: 38 g/day; Females: 25 g/day

≥51 years: Males: 30 g/day; Females: 21 g/day

Pregnancy: 28 g/day

Lactation: 29 g/day

Mechanism of Action

Wheat dextrin is a soluble fiber. It absorbs water in the intestine to form a viscous liquid which promotes peristalsis and reduces transit time.

REFERENCES

  1. Benefiber (wheat dextrin) [prescribing information]. Warren, NJ: GSK Consumer; February 2017.
  2. Benefiber Advanced Digestive Health (wheat dextrin) [prescribing information]. Warren, NJ: GSK Consumer; no date.
  3. Benefiber Healthy Shape Prebiotic Fiber Supplement (wheat dextrin) [prescribing information]. Warren, NJ: GSK Consumer; no date.
  4. Benefiber Prebiotic Fiber Supplement Chewables (wheat dextrin) [prescribing information]. Warren, NJ: GSK Consumer; no date.
  5. Benefiber Prebiotic Fiber Supplement powder (wheat dextrin) [prescribing information]. Warren, NJ: GSK Consumer; no date.
  6. IOM (Institute of Medicine), Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients), Washington, DC: The National Academies Press, 2005.
  7. James SL, Muir JG, Curtis SL, et al. Dietary fibre: a roughage guide. Intern Med J. 2003;33(7):291-296. [PubMed 12823674]
  8. Slavin JL, Savarino V, Paredes-Diaz A, et al. A review of the role of soluble fiber in health with specific reference to wheat dextrin. J Int Med Res. 2009;37(1):1-17. [PubMed 19215668]
  9. Vermorel M, Coudray C, Wils D, et al. Energy value of a low-digestible carbohydrate, NUTRIOSE FB, and its impact on magnesium, calcium and zinc apparent absorption and retention in healthy young men. Eur J Nutr. 2004;43(6):344-352. [PubMed 15309452]
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