Note: Aloquin has been discontinued in the United States for more than 1 year.
Dermatoses: Children ≥12 years and Adolescents: Topical: Apply to affected area(s) 3 to 4 times daily; Note: Due to potential toxicity (neuritis and optical atrophy) and effective alternative therapy, experts recommend against use (AAP 1990)
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
(For additional information see "Iodoquinol (topical) (United States: Systemic preparation not available): Drug information")
Note: Aloquin has been discontinued in the United States for more than 1 year.
Dermatological conditions: Topical: Apply to affected area 3 to 4 times daily or as directed.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Gel, External:
Aloquin: 1.25% (60 g [DSC]) [contains benzyl alcohol, brilliant blue fcf (fd&c blue #1), fd&c yellow #10 (quinoline yellow), propylene glycol, sd alcohol 40b, trolamine (triethanolamine)]
Quinja: 1.25% (60 g [DSC]) [contains benzyl alcohol, brilliant blue fcf (fd&c blue #1), fd&c yellow #10 (quinoline yellow), propylene glycol, sd alcohol 40b, trolamine (triethanolamine)]
No
Aloquin has been discontinued in the United States for more than 1 year.
Topical: For external use only; avoid contact with eyes. Not recommended for use under occlusive dressings or diaper areas. Discoloration of the skin, hair, and fabrics may occur.
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F)
Topical: Treatment of atopic and contact dermatitis; dermatoses (mycotic or bacterial); eczema (including impetiginized, nuchal, and nummular); endogenous chronic infectious dermatitis; stasis dermatitis; neurodermatitis (localized or disseminated); acne urticata; anogenital pruritus (vulvae, scroti, ani), pyoderma; chronic eczematoid otitis externa; folliculitis; intertrigo; lichen simplex chronicus; moniliasis (All indications: FDA approved in ages ≥12 years and adults). Note: Although FDA approved in ages ≥12 years, expert recommendations suggest that use should be avoided in pediatric patients due to potential toxicity (neuropathy, optic neuritis) and the availability of other effective treatments (AAP 1990).
There are no adverse reactions listed in the manufacturer’s labeling for the topical product.
Hypersensitivity to iodoquinol or any component of the formulation
Concerns related to adverse effects:
• Hypersensitivity reactions: Discontinue use if hypersensitivity reactions occur.
Disease-related concerns:
• Thyroid disease: Use with caution in patients with thyroid abnormalities. Thyroid function tests should not be performed for at least one month after discontinuing topical iodoquinol therapy.
Other warnings/precautions:
• Topical: For external use only. May cause discoloration of skin, hair and fabrics; can be removed with normal cleansing and laundry. Not intended for use on infants or under diapers or occlusive dressings. Prolonged use may result in overgrowth of nonsusceptible organisms.
Oral and topical halogenated hydroxyquinolines including iodoquinol are associated with serious, permanent neuropathy including optic atrophy, the most common neuropathy reported in children. The toxicity seems to be related to the dose and duration of therapy. Large, single doses have been associated with cerebral dysfunction, including disorientation and retrograde amnesia; prolonged therapy (>3 weeks) has been associated with peripheral neuropathy and optic atrophy (AAP 1974). Topical application may lead to significant systemic absorption causing toxicity. Since topical application may lead to toxicity especially in infants and children and alternative effective treatments exist, experts recommend against use (AAP 1990).
Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Shehab 2009).
None known.
There are no known significant interactions.
Information related to the use of iodoquinol in pregnancy is limited and not specific to topical use (Heinonen 1977; Vedder 1956; Verburg 1974)
Ophthalmologic exam
Amebicide that has antifungal and antibacterial properties.
Absorption: There are no data available regarding the percutaneous absorption of iodoquinol.
Gel (Quinja External)
1.25-1% (per gram): $159.36
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.