Short corneal or conjunctival procedures, ophthalmic anesthesia: Ophthalmic: Instill 2 drops of 0.5% solution 30 seconds prior to procedure; a crossover study in 22 premature neonates (GA: <30 weeks) undergoing examination for retinopathy of prematurity showed decreased pain scores compared to placebo (Marsh 2005)
Short corneal or conjunctival procedures: Infants, Children, and Adolescents: Ophthalmic: Instill 1 drop of 0.5% solution in eye every 5 to 10 minutes for 5 to 7 doses
Tonometry, gonioscopy, suture removal: Infants, Children, and Adolescents: Ophthalmic: Instill 1 to 2 drops of 0.5% solution in eye just prior to procedure
There are no dosage adjustments provided in manufacturer's labeling.
There are no dosage adjustments provided in manufacturer's labeling.
(For additional information see "Proparacaine: Drug information")
Anesthesia, ocular:
Short corneal and conjunctival procedures: Ophthalmic: Instill 1 drop in eye(s) every 5 to 10 minutes for 5 to 7 doses
Tonometry, gonioscopy, suture removal: Ophthalmic: Instill 1 to 2 drops in eye(s) just prior to procedure
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic, as hydrochloride:
Alcaine: 0.5% (15 mL) [contains benzalkonium chloride]
Generic: 0.5% (15 mL)
Yes
For ophthalmic use only. Do not use if discolored; protect eye from irritating chemicals, foreign bodies, and blink reflex; use eye patch if necessary.
Ophthalmic: Instill drops into affected eye(s); avoid contact of bottle tip with skin or eye
Ophthalmic: Do not use if discolored; protect eye from irritating chemicals, foreign bodies, and blink reflex; use eye patch if necessary
Store under refrigeration at 2°C to 8°C (36°F to 46°F). Protect from light.
Local anesthesia for tonometry, gonioscopy; suture removal from cornea; removal of corneal foreign body; cataract extraction, glaucoma surgery; short operative procedure involving the cornea and conjunctiva (FDA approved in all ages)
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Dermatologic: Allergic contact dermatitis
Hypersensitivity: Hypersensitivity reaction (corneal; characterized by acute, intense, and diffuse epithelial keratitis; gray, ground glass appearance; exfoliation of skin; corneal filaments; and can include iritis with descemetitis)
Ophthalmic: Burning sensation of eyes, conjunctival hemorrhage, conjunctival hyperemia, corneal erosion, cycloplegia, eye redness, mydriasis, stinging of eyes
Hypersensitivity to proparacaine or any component of the formulation
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only; prolonged use may result in permanent corneal opacification and visual loss and is not recommended.
None known.
Bupivacaine: Local Anesthetics may enhance the adverse/toxic effect of Bupivacaine. Management: Avoid using any additional local anesthetics within 96 hours after insertion of the bupivacaine implant (Xaracoll) or bupivacaine and meloxicam periarticular solution (Zynrelef) or within 168 hours after subacromial infiltration (Posimir brand). Risk C: Monitor therapy
Methemoglobinemia Associated Agents: May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor therapy
Animal reproduction studies have not been conducted.
Prevents initiation and transmission of impulse at the nerve cell membrane by decreasing ion permeability through stabilizing
Onset of action: Within 20 seconds of instillation
Duration: ~10 to 20 minutes
Solution (Alcaine Ophthalmic)
0.5% (per mL): $3.05
Solution (Proparacaine HCl Ophthalmic)
0.5% (per mL): $1.67 - $2.93
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