Dietary supplementation (OTC labeling): Oral: Usual dosage: One tablet or capsule daily; also see specific product labeling
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
(For additional information see "Biotin (vitamin H): Pediatric drug information")
Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents: Oral: 5 to 20 mg once daily (McVoy 1990; Micó 2011; Salbert 1993; Wolf 2003; Wolf 2010)
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
Meribin: 5 mg
Capsule, Oral [preservative free]:
Biotin Extra Strength: 10 mg [gluten free; contains soybean lecithin, soybean oil]
Generic: 5000 mcg
Tablet, Oral:
Generic: 1000 mcg, 5 mg, 10 mg
Tablet, Oral [preservative free]:
Generic: 300 mcg [DSC], 1000 mcg
Yes
Oral: May be administered without regard to meals; may be preferable to take with meals
Oral: May be administered without regard to meals; may be preferable to take with meals
Dietary supplement: As a biotin dietary supplement
There are no adverse reactions listed in the manufacturer's labeling.
Other warnings/precautions:
• RDA values: Are not requirements, but are recommended daily intakes of certain essential nutrients.
• Laboratory test interaction: Biotin in blood or other samples taken from patients who are ingesting high levels of biotin from dietary supplements (including multivitamins, prenatal multivitamins, biotin supplements, and dietary supplements for hair, skin, and nail growth) can cause clinically significant incorrect lab test results. Some testing methods use biotin technology (eg, troponin, thyroid function tests, other hormone tests), which use biotin to bind to specific proteins that are measured to detect health conditions. An increase in the number of reported adverse events, including one death, related to biotin interference with lab tests has been reported. If a lab test result does not correspond with a patient's clinical symptoms, biotin interference should be considered as a possible source of error (Bowen 2019; FDA Safety Communication 2019).
None known.
There are no known significant interactions.
Water soluble vitamins cross the placenta (IOM 1998).
Biotin is present in breast milk; concentrations may be increased by use of maternal supplements (IOM 1998).
Adequate intake (IOM 1998):
0 to 6 months: 5 mcg daily (~0.7 mcg/kg)
7 to 12 months: 6 mcg daily (~0.7 mcg/kg)
1 to 3 years: 8 mcg daily
4 to 8 years: 12 mcg daily
9 to 13 years: 20 mcg daily
14 to 18 years: 25 mcg daily
≥19 years: 30 mcg daily
Pregnancy: 30 mcg daily
Lactation: 35 mcg daily
Serum biotinidase activity
Functions as a coenzyme; involved in carboxylation, transcarboxylation, and decarboxylation reactions of gluconeogenesis, lipogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine
Capsules (Meribin Oral)
5 mg (per each): $0.28
Tablets (Biotin Oral)
5 mg (per each): $0.12
1000 mcg (per each): $0.04
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