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Zinc oxide: Drug information

Zinc oxide: Drug information
(For additional information see "Zinc oxide: Patient drug information" and see "Zinc oxide: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • AmeriDerm PeriShield [OTC];
  • Ammens® Original Medicated [OTC];
  • Ammens® Shower Fresh [OTC];
  • Balmex® [OTC];
  • Boudreaux's® Butt Paste [OTC];
  • Calazime Skin Protectant [OTC] [DSC];
  • Calmol 4 [OTC];
  • CareAll [OTC];
  • Critic-Aid Thick Moist Barrier [OTC] [DSC];
  • Desitin Maximum Strength Original [OTC];
  • Desitin Rapid Relief [OTC];
  • Dr. Smith's Diaper Rash [OTC] [DSC];
  • Elta Seal Moisture Barrier [OTC] [DSC];
  • PeriGuard [OTC];
  • Pharmabase Barrier [OTC];
  • Triple Paste [OTC];
  • Z-Guard [OTC]
Brand Names: Canada
  • Zincofax®
Pharmacologic Category
  • Antihemorrhoidal Agent;
  • Topical Skin Product
Dosing: Adult

Hemorrhoids: Rectal: Insert 1 suppository up to 6 times daily or after each bowel movement.

Protectant: Topical: Apply as required to affected areas several times daily

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Pediatric

(For additional information see "Zinc oxide: Pediatric drug information")

Note: Approved uses and ages for pediatric patients may vary by product; consult product-specific labeling.

Hemorrhoids: Children ≥12 years and Adolescents: Suppository: Rectal: Insert 1 suppository up to 6 times daily or after each bowel movement.

Skin protectant:

Infants, Children, and Adolescents: Topical:

Cream, ointment, paste, stick: Apply generously to affected area as needed, especially with each diaper change or after incontinence episodes if applicable.

Powder: Apply as needed.

Dosing: Older Adult

Refer to adult dosing.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Aerosol, topical:

Dr. Smith's Diaper Rash: 10% (100 g [DSC]) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]

Dr. Smith's Adult Barrier: 10% (100 g, 170 g) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]

Cream, topical:

Balmex: 11.3% (60 g, 120 g, 480 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]

Desitin Rapid Relief: 13% (57 g, 113 g, 454 g) [contains methylparaben and propylparaben]

Elta Seal Moisture Barrier: 6% (114 g [DSC])

Cream, topical [stick]:

Balmex: 11.3% (56 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]

Ointment, topical:

AmeriDerm PeriShield: 3.8% (100 g)

Boudreaux's Butt Paste: 16% (10 g, 28 g, 57 g, 113 g, 454 g)

CareAll: 20% (28 g, 56 g, 425 g)

Dr. Smith's Adult Barrier [OTC]: 10% (85 g)

Dr. Smith's Diaper Rash: 10% (57 g, 85 g, 227 g)

PeriGuard: 3.8% (100 g)

Pharmabase Barrier: 9.38% (500 g)

Generic: 20% (30 g, 60 g, 454 g); 40% (120 g)

Paste, topical:

Calazime Skin Protectant: 16.5% (113 g [DSC]) [contains calamine, menthol]

Critic-Aid Thick Moist Barrier: 20% (71 g, 170 g) [DSC]

Desitin Maximum Strength Original: 40% (28 g, 57 g, 85 g, 120 g, 113 g, 454 g) [contains cod liver oil and lanolin]

Triple Paste: 12.8% (57 g, 454 g, 227 g)

Z-Guard: 17% (113 g) [contains petrolatum 57% and soy protein]

Powder, topical:

Ammens® Original Medicated: 9.1% (312 g)

Ammens® Shower Fresh: 9.1% (312 g)

Suppository, rectal:

Calmol 4: 10% (12s, 24s)

Generic Equivalent Available: US

Yes: Ointment

Administration: Adult

May stain clothing and fabric.

Rectal (suppository): For rectal use only. Gently cleanse and dry anorectal area, if possible, prior to inserting suppository. Remove suppository from wrapper and insert bulb shape first into rectum.

Topical: For external use only; do not apply to eyes. Gently cleanse and dry the affected area. Apply liberally.

Administration: Pediatric

Rectal: Suppository: Gently cleanse and dry anorectal area, if possible, prior to inserting suppository. Remove suppository from wrapper and insert bulb shape first into rectum.

Topical:

Cream, paste, stick: For external use only; do not use in the eyes. Gently cleanse affected area and pat dry with a clean, soft cloth or allow to air dry. May use dry tissue to remove excess product.

Powder: For external use only; avoid contact with eyes and face or mouth (to avoid breathing in powder). Do not use on broken skin.

Use: Labeled Indications

Hemorrhoids (suppository): Temporary relief of burning, irritation, itching, and discomfort associated with hemorrhoids; protects inflamed, irritated anorectal surface to help make bowel movements less painful.

Protectant (topical products): Protective coating for mild skin irritations, poison ivy, poison oak, poison sumac, and abrasions; soothing and protective ointment to promote healing of chapped skin, diaper rash.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

1% to 10%:

Hypersensitivity: Local hypersensitivity reaction

Local: Local irritation

Warnings/Precautions

Other warnings/precautions:

• Appropriate use: Notify health care provider if condition worsens or does not improve within 7 days or if bleeding occurs.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Zinc oxide is not expected to be absorbed systemically following topical administration to healthy skin (Newman, 2009). Systemic absorption would be required in order for zinc oxide to cross the placenta and reach the fetus.

Mechanism of Action

Mild astringent with weak antiseptic properties

Pricing: US

Aerosol (Dr Smiths Adult Barrier External)

10% (per gram): $0.09

Cream (Z-Bum External)

22% (per gram): $0.43

Cream (Zinc Oxide External)

22% (per gram): $0.37

Ointment (AmeriDerm PeriShield External)

3.8% (per gram): $0.02

Ointment (Boudreauxs Butt Paste External)

16% (per gram): $0.07

40% (per gram): $0.09

Ointment (Dr Smiths Adult Barrier External)

10% (per gram): $0.08

Ointment (Dr Smiths Diaper Quick Relief External)

10% (per gram): $0.08

Ointment (Medpura Zinc Oxide External)

20% (per gram): $0.05

Ointment (Pharmabase Barrier External)

9.38% (per gram): $2.60

Ointment (Zinc Oxide External)

20% (per gram): $0.06 - $0.08

Paste (Desitin External)

40% (per gram): $0.10

Paste (Zinc Oxide External)

25% (per gram): $0.14

Suppository (Calmol-4 Rectal)

76-10% (per each): $0.69

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Brand Names: International
  • Baby Rash Free (EG);
  • Curash (AU, NZ, PH);
  • De-Rash (LK);
  • Desitin (MX);
  • Double-Care (EG);
  • Mixtura Alba (CZ);
  • Napi-Care (EG);
  • Pasta de Lassar (MX);
  • Pasta Zinci (PL);
  • Rashfree (PH);
  • Unguentum Zinci Oxydati (PL);
  • Zinxyderm (BE)


For country abbreviations used in Lexicomp (show table)

REFERENCES

  1. Ammens Medicated Powder Original (zinc oxide) [prescribing information]. El Paso, TX: Idelle Labs Ltd; May 2013.
  2. Balmex Adult Care Rash (zinc oxide) [prescribing information]. Chattanooga, TN: Chattem Inc; April 2013.
  3. Balmex Diaper Rash Stick (zinc oxide) [prescribing information]. Chattanooga, TN: Chattem Inc; January 2010.
  4. Calmol 4 Hemorrhoidal Suppositories (zinc oxide) [prescribing information]. Orchard Park, New York: Resical Inc; October 2016.
  5. Desitin Maximum Strength Original (zinc oxide) [prescribing information]. Skillman, NJ: Johnson & Johnson Consumer Products Co; November 2015.
  6. Newman MD, Stotland M, Ellis JI. The Safety of Nanosized Particles in Titanium Dioxide- and Zinc Oxide-Based Sunscreens. J Am Acad Dermatol. 2009;61(4):685-692. [PubMed 19646780]
  7. Periguard (zinc oxide) [prescribing information]. North Bergen, NJ: DermaRite Industries LLC; November 2014.
  8. Zinc oxide [prescribing information]. Sacramento, CA: Nivagen Pharmaceuticals Inc; received February 2019.
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