Primary tumor (T)* |
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
Tis | High-grade dysplasia¶ |
T1 | Tumor invades lamina propria, muscularis mucosae, or submucosa |
T1a | Tumor invades lamina propria or muscularis mucosae |
T1b | Tumor invades submucosa |
T2 | Tumor invades muscularis propria |
T3 | Tumor invades adventitia |
T4 | Tumor invades adjacent structures |
T4a | Resectable tumor invading pleura, pericardium, or diaphragm |
T4b | Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. |
Regional lymph nodes (N)Δ |
NX | Regional lymph node(s) cannot be assessed |
N0 | No regional lymph node metastasis |
N1 | Metastasis in 1 to 2 regional lymph nodes |
N2 | Metastasis in 3 to 6 regional lymph nodes |
N3 | Metastasis in seven or more regional lymph nodes |
Distant metastasis (M) |
M0 | No distant metastasis |
M1 | Distant metastasis |
Histologic grade (G) |
GX | Grade cannot be assessed - stage grouping as G1 |
G1 | Well differentiated |
G2 | Moderately differentiated |
G3 | Poorly differentiated |
G4 | Undifferentiated - stage grouping as G3 squamous |
Anatomic stage/prognostic groups |
Squamous cell carcinoma◊ |
Stage | T | N | M | Grade | Tumor location§ |
0 | Tis (HGD) | N0 | M0 | 1, X | Any |
IA | T1 | N0 | M0 | 1, X | Any |
IB | T1 | N0 | M0 | 2 to 3 | Any |
T2-3 | N0 | M0 | 1, X | Lower, X |
IIA | T2-3 | N0 | M0 | 1, X | Upper, middle |
T2-3 | N0 | M0 | 2 to 3 | Lower, X |
IIB | T2-3 | N0 | M0 | 2 to 3 | Upper, middle |
T1-2 | N1 | M0 | Any | Any |
IIIA | T1-2 | N2 | M0 | Any | Any |
T3 | N1 | M0 | Any | Any |
T4a | N0 | M0 | Any | Any |
IIIB | T3 | N2 | M0 | Any | Any |
IIIC | T4a | N1-2 | M0 | Any | Any |
T4b | Any | M0 | Any | Any |
Any | N3 | M0 | Any | Any |
IV | Any | Any | M1 | Any | Any |