Comorbidity |
CCI definition |
CCI score |
HCT-CI definition |
HCT-CI score |
Pulmonary disease |
Mild |
Dyspnea on moderate activity (or with asthma attacks) |
1 |
Dyspnea on moderate activity or DLco and/or FEV1 81 to 90 percent |
0 |
Moderate |
Dyspnea on slight activity |
1 |
Dyspnea on slight activity or DLco and/or FEV1 66 to 80 percent |
2 |
Severe |
Dyspnea at rest or requires oxygen |
1 |
Dyspnea at rest or requires oxygen or DLco and/or FEV1 ≤65 percent |
3 |
Cardiac disease |
General |
Congestive heart failure (symptomatic and requiring treatment) and myocardial infarction were included as independent comorbidities, each acquiring a score of 1 |
1 or 2 |
Coronary artery disease*, congestive heart failure, myocardial infarction, or EF ≤50 percent |
1 |
Arrhythmia |
N/A |
0 |
Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias |
1 |
Heart valve disease |
Except mitral valve prolapse |
0 |
Except mitral valve prolapse |
3 |
Hepatic disease |
Mild |
Chronic hepatitis or cirrhosis |
1 |
Chronic hepatitis, bilirubin >ULN to 1.5 X ULN, or AST/ALT >ULN to 2.5 X ULN |
1 |
Moderate to severe |
Cirrhosis with portal hypertension ± bleeding varices |
3 |
Cirrhosis or fibrosis or bilirubin >1.5 X ULN or AST/ALT >2.5 X ULN |
3 |
Renal disease |
Mild |
Serum creatinine 2 to 3 mg/dL |
0 |
Creatinine 1.2 to 2 mg/dL |
0 |
Moderate to severe |
Creatinine >3 mg/dL, renal dialysis, or renal transplant |
2 |
Creatinine >2 mg/dL, renal dialysis, or renal transplant |
2 |
Other malignancies |
Prior solid tumor |
Initially treated in the last five years |
2 |
Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer |
3 |
Metastatic cancer |
Present |
6 |
Not included |
N/A |
Other comorbidities |
Diabetes |
Requiring treatment with insulin or oral hypoglycemics but not diet alone |
1 |
Requiring treatment with insulin or oral hypoglycemics but not diet alone |
1 |
Cerebrovascular disease |
Transient ischemic attack or cerebrovascular accident |
1 |
Transient ischemic attack or cerebrovascular accident |
1 |
Rheumatologic |
SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica |
1 |
SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica |
2 |
Peptic ulcer |
Requiring treatment |
1 |
Requiring treatment |
2 |
Psychiatric disturbance |
Not included |
N/A |
Depression or anxiety requiring psychiatric consult or treatment |
1 |
Infection |
Not included |
N/A |
Requiring continuation of antimicrobial treatment after day 0 |
1 |
Inflammatory bowel disease |
Not included |
N/A |
Crohn disease or ulcerative colitis |
1 |
Obesity |
Not included |
N/A |
Patients with a body mass index >35 kg/m2 |
1 |