INTRODUCTION — An aneurysm is an abnormal focal arterial dilation. Pre-existing aneurysms can become secondarily infected, but aneurysmal degeneration of the arterial wall can also be the result of infection that may be due to bacteremia or septic embolization, as in the case of mycotic aneurysm. The name mycotic aneurysm was coined by Osler to describe aneurysms associated with bacterial endocarditis [1]. These were noted to have the appearance of "fresh fungus vegetations"; however, the majority of mycotic aneurysms are caused by bacteria. Although some authors use the term "mycotic" to describe infected aneurysm regardless of etiology, we will limit the use of this term to those aneurysms that develop when material originating in the heart causes arterial wall infection and, subsequently, dilation [2].
Aneurysms are classified into true and false, or pseudoaneurysms. True aneurysms involve all three layers of the arterial wall (intima, media, and adventitia). A false, or pseudo-, aneurysm is a collection of blood or hematoma that has leaked out of the artery but is then confined by the surrounding tissue.
Infected aneurysm is a serious clinical condition that is associated with significant morbidity and mortality. Treatment consists of antibiotic therapy combined with aggressive surgical debridement of the infected tissue and vascular reconstruction, as needed. Endovascular therapies may have a role in the treatment of ruptured infected aneurysm and the treatment of patients at prohibitive risk for open surgery.
The pathogenesis, microbiology, clinical manifestations, diagnosis, and treatment of infected arterial aneurysm is reviewed.
The diagnosis and management of noninfected aneurysms are discussed in separate topic reviews. (See "Unruptured intracranial aneurysms" and "Extracranial carotid artery aneurysm" and "Management of thoracic aortic aneurysm in adults" and "Overview of aneurysmal disease of the aortic arch branches or upper extremity arteries in adults" and "Management of asymptomatic abdominal aortic aneurysm" and "Overview of visceral artery aneurysm and pseudoaneurysm" and "Iliac artery aneurysm" and "Femoral artery aneurysm" and "Popliteal artery aneurysm".)
RISK FACTORS — Risk factors for infected aneurysm include:
●Arterial injury – Arterial injury is an important risk factor for an infected aneurysm. Artery injury resulting in infected femoral artery pseudoaneurysm is commonly due to intravenous drug use (self-inflicted), but iatrogenic mechanisms, such as invasive monitoring, percutaneous access for cardiac catheterization, or other peripheral interventions, can also lead to infected aneurysm [3,4]. Arterial injury may result from other mechanisms, such as gastrointestinal perforation [5,6] or peripheral nerve block [7]. (See 'Direct bacterial inoculation' below.)
●Antecedent infection – In a retrospective review, nearly half of 43 patients with an infected aortic aneurysm were found to have an antecedent infection that included pneumonia, cholecystitis, urinary tract infection, endocarditis, diverticulitis, soft tissue infection, and osteomyelitis. In the pre-antibiotic era, the majority of infected aneurysms were due to endocarditis. More contemporary series identify endocarditis as the likely etiology in 17 to 29 percent of cases [8,9]. The rapid development of an infected aortic aneurysm associated with periodontal infection and oral surgery has also been reported [10-13]. (See 'Septic emboli (mycotic aneurysm)' below.)
●Impaired immunity – Immunosuppressive states predispose the patient to infection, which may present with atypical clinical features. Immunosuppressive disorders were found in 70 percent of patients with infected aneurysms in a review of 43 patients [14]. Diabetes, alcoholism, chronic glucocorticoid therapy, chemotherapy, and malignancy have been identified as possible risk factors for infected aneurysm [14-18]. Immune mechanisms may play a role in the development of infected aneurysm in a variety of other circumstances, such as in patients with cancer [19], cirrhosis [20], those undergoing hemodialysis [21], following gastrointestinal endoscopy [22], posttransplant, those with HIV infection [23-25], and following trauma or near drowning [26]. (See 'Bacteremic seeding' below.)
●Atherosclerosis – Patients with atherosclerosis, particularly older adults, are at risk for bacteremic seeding of atheromatous plaques. (See 'Bacteremic seeding' below.)
●Pre-existing aneurysm – Pre-existing aneurysms are at risk for secondary infection due to bacteremia or spread from a contiguous infection. The prevalence of infection in a pre-existing aneurysm is low. In a study that cultured aortic tissue from patients undergoing elective aneurysm repair, positive cultures were obtained in 33 of 88 patients [27]. Positive cultures were associated with subsequent infected grafts in three patients. However, the majority of patients with positive aortic cultures had no known negative sequelae. (See 'Bacteremic seeding' below and 'Contiguous infection' below.)
ETIOLOGY
Direct bacterial inoculation — Direct inoculation of bacteria into the arterial wall can occur at the time of vascular injury. An arterial injury may be self-inflicted, iatrogenic, accidental, or due to assault (gunshot, stab). Infected pseudoaneurysm following arterial injury has become one of the most common forms of infected aneurysm. The femoral artery is the most commonly involved arterial site.
Self-induced infected pseudoaneurysms are the result of injection drug abuse wherein users inadvertently inoculate themselves via contaminated needles into the arterial wall (they are aiming for the adjacent veins) or a surrounding hematoma. Infected pseudoaneurysms of the common femoral artery are most common, but infection involving the external iliac, carotid, and subclavian arteries have also been reported.
Bacteremic seeding — Bacteremic seeding of an existing intimal injury, atherosclerotic plaque, or pre-existing aneurysm can lead to arterial wall infection.
The intima is normally highly resistant to infection, but, when diseased, it allows bacteria to pass through it into deeper layers of the arterial wall. Once a local infection is established, suppuration, localized perforation, and pseudoaneurysm can result. The aorta is the most common location affected primarily since it is the most frequent site of atherosclerosis, but peripheral arteries can also be affected. Infected aneurysm can occur in the absence of significant atherosclerosis [28].
In a similar manner, pre-existing aneurysms may become secondarily infected, which may predispose to rupture. In a study of 80 patients undergoing open aortic repair, a greater number of positive cultures were found in patients with ruptured aneurysms compared with asymptomatic and symptomatic aneurysms (38 versus 9 and 13 percent, respectively) [29]. Rupture of abdominal aortic aneurysms is discussed elsewhere. (See "Management of symptomatic (non-ruptured) and ruptured abdominal aortic aneurysm", section on 'Introduction'.)
Contiguous infection — A focus of infection can extend to the arterial wall. Extension of a postoperative infection can lead to an infected aneurysm and has been described in the setting of appendectomy [30], cholecystectomy [31], colorectal surgery [32,33], as a result of pancreatic pseudocyst [34], and following knee or hip replacement surgery [35-37]. Extension of infection not related to surgery can also occur as seen in vertebral osteomyelitis [38-40].
Septic emboli (mycotic aneurysm) — Septic embolic from the heart can occlude the vasa vasorum of the vessel or the vessel lumen, leading to vascular wall infection and mycotic aneurysm formation. Embolism is estimated to occur in between 25 and 50 percent of patients, but only about 1 to 5 percent develop symptomatic mycotic aneurysm [41]. Because of their embolic nature, mycotic aneurysms tend to be multiple, but they can also be solitary [42]. Spontaneous resolution with antibiotic therapy for endocarditis has been reported [43-45]. As such, the true prevalence of mycotic aneurysm is unknown.
Mycotic aneurysms can develop anywhere but are most commonly seen in the intracranial arteries, followed by visceral arteries and upper or lower extremity arteries, typically occurring at arterial bifurcations [41]. One study included 151 patients with endocarditis who underwent cerebral angiography as a part of preoperative evaluation; a mycotic aneurysm was found in seven (4.6 percent) of these patients [46]. In a further study of 81 patients with left-sided endocarditis who underwent routine brain computed tomography (CT) and CT angiography, 26 had intracranial mycotic aneurysms [47]. Mycotic aneurysms of coronary arteries, although rare, have also been described [48]. In one review including 922 cases of definite infective endocarditis, symptomatic peripheral mycotic aneurysm was observed in 2 percent of cases; of these, 66 percent were intracranial (in the region of the middle cerebral artery) and 34 percent were extracranial [42]. Six peripheral artery aneurysms were identified: two in popliteal and one each in the ulnar artery, humeral artery, hepatic artery, and coronary artery.
MICROBIOLOGY — Blood cultures are positive in 50 to 85 percent of cases [49,50]. Organisms have been isolated from aneurysmal tissue in up to 76 percent of patients [29,49]. In one case series, multiple organisms were isolated in 8 percent, and no pathogen was identified in 25 percent of cases [8]. Identification of the causative organism using molecular methods (bacterial 16S ribosomal RNA) has been described [51].
Although bacteriologic patterns continue to evolve over time, the organisms with the greatest affinity for the arterial wall, Staphylococcus spp and Salmonella spp, remain the most common [52-54]. Staphylococcus aureus is the most common pathogen reported in 28 to 71 percent of cases [8,49]. In several reports of infected aneurysms, methicillin-resistant S. aureus (MRSA) predominates [55-57]. In one series of pre-existing aneurysms, Staphylococcus epidermidis was the most prevalent organism [29]. Infected aneurysm due to vancomycin-intermediate S. aureus (VISA) has also been described [58].
Salmonella is reported in 15 to 24 percent of cases [8,52,59]. The diseased aorta appears to be vulnerable to Salmonella, and this pathogen is frequently isolated in infected aneurysms due to bacteremic seeding of atherosclerotic plaque [60].
Streptococcus pneumoniae was a frequent etiology of infected aneurysms in the pre-antibiotic era but became rare with the advent of penicillin; however, S. pneumoniae may be re-emerging as a cause of infected aneurysms [61,62].
Other gram-negative organisms are also associated with bacteremic seeding [32,63-65]. In one study, although gram-positive organisms predominated, gram-negative organisms were seen in 35 percent of cases [65]. In this study, gram-negative infections were associated with a higher incidence of aneurysm rupture (84 versus 10 percent) and mortality (84 versus 50 percent) compared with gram-positive organisms.
Less common causes of infected aneurysm include Treponema pallidum and Mycobacterium spp including Mycobacterium bovis BCG [66-71]. Syphilis (T. pallidum) once caused up to 50 percent of infected aneurysms (image 1). Tuberculosis is a rare cause of infected aneurysms and is most often due to erosion of periaortic lymph nodes into the aortic wall. One review of cases of infected aneurysm caused by Mycobacterium tuberculosis found only 41 cases between 1945 and 1999 [72].
Coxiella burnetii can also be the cause of an infected aneurysm [73-77]. A C. burnetii–infected aneurysm can occur without other manifestations of chronic Q fever [73].
Fungal arterial infections are also rare but may occur in patients with immune suppression, diabetes mellitus, or following treatment of a disseminated fungal disease. Pathogens include Candida [78], Cryptococcus [79], Aspergillus [80], Pseudallescheria boydii [26], and Scedosporium apiospermum [81].
Many other organisms have also been reported to cause infected aneurysms, including:
●Other gram-positive organisms (eg, non-pneumococcal Streptococcus [82], Clostridium [83], Corynebacterium [84], Rothia dentocariosa [85], Listeria [25,86,87], Lactococcus cremoris [88]), and Staphylococcus lugdunensis [89]
●Other gram-negative organisms (eg, Pseudomonas [63], Klebsiella [90], E. coli [64], Campylobacter [91,92], Yersinia [93,94], Brucella [95,96], Haemophilus influenzae [97], Acinetobacter [98], Burkholderia pseudomallei [melioidosis] [99-104]) and Campylobacter [105,106]
●Anaerobes (eg, Bacteroides [107]), Eikenella [108], and Clostridium septicum [109]
CLINICAL MANIFESTATIONS
Classic presentation — The classic presentation of an infected aneurysm is a painful, pulsatile, and enlarging mass together with systemic features of infection, such as fever. This presentation is more likely to be found for infected aneurysms that are superficial in location (eg, common femoral artery). In one series of 52 infected aneurysms among intravenous drug users, a tender indurated mass was palpated in 92 percent of cases; these were pulsatile in 52 percent of cases [49]. A bruit was heard in 50 percent of cases, fever was observed in 48 percent, and there was bleeding at the injection site in 15 percent of cases. In some cases, infected aneurysm may be masked by overlying inflammation. Thus, the presence of a soft tissue infection in association with a major blood vessel should raise suspicion for an infected aneurysm. Infected aneurysm can be easily misdiagnosed as cellulitis, abscess, or thrombophlebitis.
For deeper sites, the aneurysm may not be palpable and may be apparent only on imaging studies. Infected aneurysms involving the aorta or iliac arteries may be accompanied by abdominal or back pain. On the other hand, patients with infected aortic aneurysm may manifest only with fever of unknown origin, some of whom will remain undiagnosed until rupture. (See "Clinical features and diagnosis of abdominal aortic aneurysm".)
Infected aortic aneurysm must be distinguished from inflammatory aortic aneurysm, which can have similar clinical features, such as fever, weight loss, nonspecific abdominal pain, and elevated erythrocyte sedimentation rate [110]. Inflammatory aneurysms are characterized by an inflammatory infiltrate in the aortic adventitia associated with adventitial fibrosis. Diagnostic signs on abdominal computed tomography help to differentiate these. (See 'Differential diagnosis' below.)
Infected aneurysm of the intracerebral vessels may present as stroke or subarachnoid hemorrhage, particularly in the setting of endocarditis.
Other presentations — Undiagnosed, infected aneurysms can lead to progressive infection, sepsis, hemorrhage or thrombosis leading to ischemic symptoms, the manifestations of which depend on location. Some of these include:
●Gastrointestinal bleeding – Although gastrointestinal bleeding is more commonly caused by an infected aortic graft, a primary aorto-duodenal fistula may be due to an infected aortic aneurysm by erosion of the vessel into the third portion of the duodenum [55,111,112]. Rupture of an infected aneurysm into other gastrointestinal structures, such as the appendix [113] or esophagus [114], can also occur. (See "Aortoenteric fistula: Recognition and management".)
●Heart failure – As with noninfected aneurysms, rupture of an infected aneurysm into a vein results in an arteriovenous fistula [115]. If a large-enough artery and vein are involved (eg, aortocaval fistula), high output heart failure may result. (See "Causes and pathophysiology of high-output heart failure".)
●Acutely expanding hematoma – For infected aneurysms that are superficial, the hematoma will be easily seen. Retroperitoneal hematoma from infected aortic or iliac aneurysm rupture may lead to hypovolemic shock. (See "Management of symptomatic (non-ruptured) and ruptured abdominal aortic aneurysm", section on 'Introduction'.)
●Acute or chronic mesenteric ischemia – Infected aneurysm of the superior mesenteric artery may acutely thrombose or embolize into the terminal mesenteric branches, leading to symptoms of intestinal ischemia. (See "Overview of intestinal ischemia in adults" and "Acute mesenteric arterial occlusion" and "Chronic mesenteric ischemia".)
●Peripheral ischemia – Infected aneurysm of the peripheral arteries may acutely thrombose or embolize distally. (See "Clinical features and diagnosis of acute lower extremity ischemia" and "Embolism to the lower extremities".)
●Dysphagia and hoarseness – Enlarging or ruptured carotid or subclavian artery aneurysm may compress the structures of the neck leading to stenosis or deviation of the trachea [116] or impingement of the laryngeal nerves. (See "Extracranial carotid artery aneurysm" and "Overview of aneurysmal disease of the aortic arch branches or upper extremity arteries in adults".)
●Hemoptysis – A mass due to a pulmonary artery aneurysm may be seen during bronchoscopy [117]. Rupture of pulmonary artery aneurysm may lead to massive hemoptysis [118]. (See "Evaluation and management of life-threatening hemoptysis".)
●Osteomyelitis – Infection of the aorta may extend to thoracic or lumbar spine [119]. (See "Vertebral osteomyelitis and discitis in adults", section on 'Clinical features'.)
●Psoas abscess – Extension of infection from an aortic or iliac aneurysm to the psoas muscle may cause flank pain, inguinal pain, and limping [90]. (See 'Clinical manifestations' above and "Psoas abscess".)
●Neuropathy – Infected aneurysms can impinge on the nerves supplying the extremities [120]. (See "Overview of upper extremity peripheral nerve syndromes" and "Overview of lower extremity peripheral nerve syndromes".)
DIAGNOSIS
Clinical approach — Suspicion of an infected aneurysm based upon history and physical findings should be followed up with laboratory and imaging studies. The diagnosis of an infected aneurysm is based upon imaging the aneurysm, and infection is confirmed by culturing an organism from the blood. Computed tomography (CT) angiography definitively diagnoses the aneurysm, specific features suggest infection, and CT also simultaneously evaluates the status of the circulation [121]. (See 'Vascular imaging' below.)
On laboratory examination, an increased white blood cell count is found in 64 to 71 percent of patients [52,122,123]. Inflammatory markers, including C-reactive protein and erythrocyte sedimentation rate, are generally elevated.
Cultures — Blood cultures (aerobic, anaerobic, fungal) should be obtained in any patient with a suspected infected aneurysm. Because blood culture may be negative in 25 to 50 percent of patients, negative blood cultures alone are not sufficient to rule out infected aneurysm.
An infected aneurysm may be first suspected in the operating room based upon purulence in association with a pre-existing aneurysm [124]. Tissue samples of the aneurysm wall should be sent for culture (aerobic, anaerobic, fungal) and Gram stain. In the operating room, a negative Gram stain is not sufficient to exclude a diagnosis of infected aneurysm [122]. Conversely, positive tissue cultures in the absence of clinical findings do not confirm an infected aneurysm in the absence of appropriate clinical findings. In one study, 69 percent of patients had positive preoperative blood cultures and 92 percent had positive aneurysm wall cultures, but the operative Gram stain was positive in only 50 percent of patients with ruptured infected aneurysms and 11 percent of unruptured but infected aneurysms [122].
Molecular methods for identification of the causative organism from operative aneurysm tissue have been described [125,126]. Such methods warrant pursuit if initial cultures are negative.
Vascular imaging — Imaging studies for detection of intracranial mycotic aneurysm include CT angiography, magnetic resonance (MR) angiography, and digital subtraction angiography (DSA) [41]. Of these, CT angiography is the most useful for diagnosing infected aneurysm [127]. MR angiography is an alternative diagnostic study when intravenous contrast is contraindicated [128]. When vascular imaging is consistent with an infected aneurysm, we prefer to perform additional imaging of the remainder of the vasculature to identify multifocal disease. In the setting of high clinical suspicion for intracranial mycotic aneurysm with negative imaging results, conventional angiography is reasonable [41].
Findings on CT angiography suggestive of an infected aneurysm include the following [127,129-133] :
●Saccular, eccentric aneurysm or multilobulated aneurysm
●Soft tissue inflammation or mass around a vessel
●Aneurysm with intramural air or air collection around the vessel
●Perivascular fluid collection
In the mesenteric circulation, indistinct fat planes may be indicative of vascular inflammation [134,135]. If a diagnosis of infected aneurysm remains in doubt, a repeat scan can be performed after a short interval to evaluate for rapid enlargement or changes to the aneurysm that suggest infection [130-132].
Ultrasound is useful for diagnosing the presence of an aneurysm; however, findings on ultrasound are not reliable for delineating the presence or extent of infection. (See "Clinical features and diagnosis of abdominal aortic aneurysm", section on 'Diagnosis'.)
DSA is not reliable for identifying infected aneurysm; DSA is also invasive and associated with potential hazards. Nuclear medicine studies, including fluorodeoxyglucose-positron emission tomography (FDG-PET) and gallium scanning, are alternative modalities for evaluating infected aneurysm [136-142]. The use of FDG-PET/CT in the diagnosis of infected aneurysms has been described in case series [74,143].
Imaging studies for detection of extracranial mycotic aneurysm include CT or multislice CT angiography with 3D reconstruction. Transesophageal echocardiography (TEE) is useful for identifying mycotic aneurysm of the sinus of Valsalva and thoracic aorta [41].
DIFFERENTIAL DIAGNOSIS — Infected aneurysms need to be differentiated from inflammatory vascular changes (eg, Takayasu arteritis, giant cell arteritis, other forms of aortitis or other large vessel vasculitis, idiopathic [eg, inflammatory abdominal aortic aneurysm (AAA)]). Patients with inflammatory aneurysms often have findings suggestive of perivascular fibrosis with adhesions to adjacent structures. Inflammatory aneurysms are not associated with periaortic air or fluid and are not infected.
As an example, an inflammatory AAA is defined as an aneurysm with a ≥1 cm thickness inflammatory rind surrounding the aorta on abdominal computed tomography. The periaortic soft tissue density sometimes enhances with intravenous contrast and the ureters may be deviated medially [110]. Periaortic fibrosis may result in adhesions between the aorta and the ureters or duodenum, leading to indistinct retroperitoneal tissue planes on imaging studies. (See "Clinical features and diagnosis of abdominal aortic aneurysm", section on 'Infected versus inflammatory AAA'.)
MANAGEMENT — There are no randomized trials to guide the management of infected aneurysms. Management strategies are primarily based upon clinical experience guided by case series. The standard treatment of most infected aneurysms is antibiotic therapy combined with surgical debridement with or without revascularization [122]. Revascularization procedures are performed, as needed, depending upon the affected vascular bed and status of distal perfusion. For patients who refuse surgery or who have significant medical comorbidities that preclude surgical intervention, antibiotic therapy alone is an option. Endovascular techniques are emerging as a treatment alternative for infected aneurysm, most commonly for infected aortic aneurysms [121,144-155]. (See 'Role of endovascular techniques' below.)
Antibiotic therapy — The initial choice of antibiotic therapy should be guided by the most likely infecting organism based upon the clinical circumstances. Prior to the availability of culture results, we favor treatment with a combination of vancomycin and an agent with activity against gram-negative organisms, especially Salmonella and enteric gram-negatives; reasonable choices include ceftriaxone, a fluoroquinolone, and piperacillin-tazobactam. Antibiotics should be tailored to culture and susceptibility results when they become available.
The optimal duration of antibiotic therapy is uncertain and depends on factors, including the immune competence of patient, location of infection, specific bacteria, autogenous versus prosthetic grafts, in situ versus extraanatomic reconstruction, and response to treatment (fever, white count, hemodynamic stability). In general, at least six weeks of parenteral and/or oral antimicrobial therapy is administered for treatment of infected aneurysm. If surgical drainage is performed, this time period commences from the day of surgery. However, there are no data to support a specific duration of antibiotic therapy; in some circumstances, particularly for cases in which autologous vein grafting is used, a shorter duration may be sufficient. A longer duration of treatment may be warranted in the setting of antibiotic-resistant organisms, persistently positive cultures, and/or inflammatory markers that are slow to normalize [156]. Suppressive oral antibiotics following completion of intravenous therapy may be warranted for patients reconstructed with prosthetic graft material in situ during active infection [8,157,158].
Surgery — Management of infected aneurysms follows the general principles of managing vascular graft infection. The main surgical aim is removal of all necrotic and infected tissue and management of any ensuing ischemia. The decision to pursue vascular reconstruction depends primarily upon the patient's underlying vascular status and the anatomic site of the aneurysm (which determines the likelihood of ischemia distal to the site following aneurysm excision) but also on the availability of autologous graft material [157,159-165]. In many cases, the approach may need to be changed during the course of surgical exploration.
Aneurysm excision and ligation without arterial reconstruction — Following proximal and distal control of the involved artery, the infected aneurysm and surrounding infected tissue are excised. The major inflow and outflow vessels to the aneurysm should be dissected back to normal tissue. These vessels are oversewn with permanent suture and ligated 1 to 2 cm more proximally to prevent blowout of the arterial stump. Smaller branches can be suture ligated. Antegrade instillation of heparin into the ligated artery may help preserve arterial collaterals, but ongoing anticoagulation therapy is generally not needed.
Excision with immediate reconstruction — Some form of immediate arterial reconstruction will be required in patients who are likely to develop acute ischemia with arterial ligation. The disadvantage of immediate reconstruction is the potential for recurrent infection or hemorrhage due to breakdown of the anastomoses. The decision to perform in situ repair or extraanatomic bypass depends upon a variety of factors, including the anatomic site and presence and severity of peripheral artery disease, but the nature and virulence of the infection also play a role. Many successful in situ reconstructions using autogenous vein and antibiotic impregnated grafts have been performed for primary arterial infections, including those due to Salmonella [157,166] and Staphylococcus epidermidis [167]. (See 'Thoracic aorta' below and 'Abdominal aorta and iliac arteries' below.)
In some cases, it may be preferable to perform an extraanatomic bypass prior to excision of the aneurysm to minimize the duration of ischemia. In situ reconstruction may be necessary for some anatomic sites (eg, thoracic aorta, suprarenal abdominal aorta). On the other hand, a limited infection that is effectively cleared following debridement may be a candidate for in-line autogenous vein reconstruction, but this practice is debated. The selection of patients, timing, and methods of reconstruction, particularly when the infected aneurysm involves the aorta or the carotid or femoral artery, remain controversial. (See 'Specific anatomic sites' below.)
When autogenous superficial vein (eg, great saphenous vein, small saphenous vein, or arm vein) is not available or is inadequate (diameter, length, quality), options include femoral-popliteal deep vein [168,169], cryopreserved homograft [170-174], and prosthetic grafts with or without antibiotic impregnation [161,175]. The vascular anastomotic sites and conduit should be covered by healthy tissue, which may require rotation of a local muscle flap (eg, sartorius flap, rectus, or gracilis) [176]. The use of prosthetic grafts is associated with higher rates of reinfection.
Excision with interval reconstruction — When possible, an alternative strategy involves aneurysm excision and debridement with an interval of treatment with antibiotics prior to vascular reconstruction. This option should be considered for patients who are expected to develop only mild to moderate limb ischemia. Unfortunately, it is sometimes difficult to predict intraoperatively whether or not ischemia will become progressive.
Role of endovascular techniques — Endovascular therapy may be most suitable for the management of infected aneurysm in high-risk patients for whom mortality rates for open surgery would be prohibitive. Endovascular management may also be beneficial for patients with aneurysm rupture, as a temporizing measure, until definitive debridement and reconstruction can be performed under more "elective" circumstances [177-182]. Lastly, endovascular embolization techniques may be appropriate in managing some infected pseudoaneurysms [183,184]. (See "Endovascular repair of the thoracic aorta" and "Endovascular repair of abdominal aortic aneurysm" and "Open surgical repair of abdominal aortic aneurysm".)
Thoracic endovascular graft repair of infected aneurysm has been reported in case reports and small case series [145-147,185-190]. The largest of these series involved thoracic endovascular infected aneurysm repair in 20 patients with etiologies that included one fusiform aneurysm and 18 pseudoaneurysms [186]. Three patients died perioperatively. Three additional deaths were attributed to recurrent infection that appeared to be related to infection of the endograft. Overall mortality was 65 percent with a mean survival of 39 ± 9 months with many deaths related to underlying comorbidities. For patients who have significant comorbidities, thoracic endovascular repair may be an appropriate palliative option given the even higher mortality associated with open surgery in a subset of patients.
A systematic review evaluated endovascular management of 91 infected aortic aneurysms (thoracic and abdominal aorta), finding a 90 percent 30-day survival rate and an 82 percent two-year survival [146]. Logistic regression identified aneurysm rupture and fever as independently associated with persistent infection and mortality. Even when long-term antibiotic therapy has been provided, persistent or recurrent infections occur. In a multicenter study that included 123 patients with infected aneurysm and treated using endovascular stent grafts, infection-related death occurred in 23 patients (19 percent), 9 after the discontinuation of antibiotics [144]. Reoperation is associated with high rates of morbidity and mortality [146,151,191,192]. Given that debridement of the infected tissues is not accomplished, the reinfection and late failure rates are not surprising. In a later nationwide study from Sweden, 132 patients were identified as having infected abdominal aortic aneurysm based upon a combination of clinical, laboratory, and radiologic features [193]. The preferred operative technique shifted from open surgery to endovascular repair after 2001 with the proportion of endovascular repairs increasing from 0 to 60 percent between 1994 and 2014. Overall, open repair was performed in 62 patients (47 percent) and endovascular repair was performed in 70 patients (53 percent); no deaths occurred intraoperatively. Survival at 3 months was significantly higher for endovascular compared with open repair (96 versus 74 percent) but not significantly different at later follow-up (1 year: 84 versus 73 percent; 5 year: 58 versus 60 percent). There were also no significant differences in infection-related complications (24 versus 18 percent) or reoperation (24 versus 21 percent). It is possible that improvements in intensive care and antimicrobial therapy may explain the improved outcome for more recent cases treating infected aneurysm with endovascular aortic repair, regardless of the type of surgery.
SPECIFIC ANATOMIC SITES
Intracranial — Cerebral mycotic aneurysms tend to occur in the more distal portions of the middle cerebral artery involving the secondary and tertiary branches near the brain surface. This characteristic pattern helps to distinguish them clinically from berry aneurysms, which tend to occur near the base of the brain and the circle of Willis [194]. In one review including 820 patients, 63 percent of cerebral mycotic aneurysms were on the middle cerebral artery [195]. (See "Unruptured intracranial aneurysms".)
A review of intracranial infected aneurysms complicating endocarditis found that the most important factor when considering treatment of cerebral aneurysms is whether the aneurysm has ruptured [196]. Treatment-related mortality was higher in patients with ruptured aneurysms than in patients with unruptured aneurysms (24 versus 9 percent, respectively). Among patients with ruptured aneurysms, mortality was higher in those treated with antibiotics alone compared with those treated with both antibiotics and surgery (49 versus 12 percent).
For these reasons, unruptured aneurysms may be managed with antibiotics alone, but, whenever possible, ruptured aneurysms should be managed with a combination of antibiotics and surgery [197]. Several studies report obliterating infected cerebral aneurysms using endovascular techniques [198-200]. Increasingly, endovascular management is being used for infected intracranial aneurysms [201].
Thoracic aorta — Infected aneurysm of the thoracic aorta is rare [202]. Most reported series have fewer than 50 patients [203-208]. In one of the larger case series involving 32 primary infected aneurysms, the morphology was primarily pseudoaneurysm [205]. The distribution between the aortic arch and descending aorta was equal.
Thoracic endovascular aortic repair is becoming the preferred treatment (provided there is no aero-digestive communication) for patients with infected thoracic aortic pseudoaneurysm, given the high morbidity and mortality associated with open surgical repair in these patients, who tend to be older and have significant cardiovascular risk factors. (See "Endovascular repair of the thoracic aorta".)
Debridement and in situ reconstruction of the thoracic aorta remains the preferred approach for thoracic aortic graft infection. Following debridement, surgical reconstruction techniques are similar to those used to repair noninfected aneurysm. (See "Overview of open surgical repair of the thoracic aorta".)
In the above-mentioned series, clinical symptoms consisted of fever, chest pain, hemoptysis, respiratory failure, hoarseness, loss of consciousness, and stroke [205]. The most common microorganisms were nontyphoid Salmonella (57 percent) and S. aureus (14 percent). Among patients who underwent surgery (debridement and in situ reconstruction), morbidity and one-year mortality rates were the highest for patients with infected arch aneurysms (70 and 50 percent, respectively) compared with infected proximal descending (33 and 16 percent, respectively) or distal descending aneurysms (56 and 33 percent, respectively). Mortality among patients who were managed without surgery (antibiotics only) was 85 percent, with two-thirds of these due to in-hospital rupture. In another series that included aortic aneurysm, no patient who had a ruptured infected aneurysm survived [209].
Abdominal aorta and iliac arteries — Mortality related to infected aortic aneurysm is lower when medical and surgical therapies are combined (38 versus 96 percent) compared with medical treatment alone. Following debridement of an infected infrarenal aortic aneurysm, extraanatomic reconstruction (eg, axillofemoral bypass) is generally preferred [159,210-212]. Placement of prosthetic graft material into the infected retroperitoneum is associated with a 25 percent reoperation rate that increases to 63 percent when the infecting organism is a gram-negative organism [160,213]. As an alternative, autogenous vein can be used. The incidence of reinfection is low when neoaortic iliac system reconstruction is used [214]. On the other hand, a disadvantage of axillobifemoral bypass is the greater potential for graft thrombosis compared with aortofemoral reconstruction. (See "Open surgical repair of abdominal aortic aneurysm".)
For infected suprarenal aneurysm, in situ repair is generally performed to preserve visceral flow, though, in some cases, in situ reconstruction is not possible and extraanatomic bypass is necessary [152,165,215-217]. In one study of 28 patients with primary infection of the aorta, no significant difference in mortality was found for patients undergoing in situ reconstruction compared with extraanatomic bypass [166].
For infected aortic aneurysms, perioperative mortality is 15 to 20 percent. The morbidity and mortality of infected aneurysm is related to inability to clear the infection and development of end-organ ischemia [14,52,122,123]. Survival is better for infrarenal abdominal aortic aneurysms (96 versus 57 percent) compared with non-infrarenal aneurysms. Late complications are common, occurring in 30 to 70 percent of patients, and are frequently a cause of death [166,205].
Extracranial carotid artery — The innominate artery and common carotid artery may tolerate ligation without reconstruction; however, ligation of the internal carotid artery is associated with a 30 to 40 percent incidence of stroke [218-220]. Alternatively, a test occlusion of the internal carotid artery can be performed, and reconstruction performed selectively for those who develop signs of cerebral ischemia [221]. However, most surgeons favor immediate reconstruction with autogenous vein [222]. A case report detailed the repair of a ruptured infected carotid arterial pseudoaneurysm using a superficial femoral artery graft [223]. (See "Extracranial carotid artery aneurysm", section on 'Open surgical repair'.)
Lower extremity — Infected aneurysms of the lower extremity arteries most commonly involve the vessels in the groin. The popliteal or peroneal arteries can be affected, but infected aneurysm of the vessels below the knee is generally rare [224,225]. Lower extremity-infected aneurysm presents as a painful pulsatile mass, acute limb ischemia due to aneurysm thrombosis, rupture, or distal embolization, similar with noninfected lower extremity aneurysm. (See "Femoral artery aneurysm", section on 'Clinical presentation' and "Popliteal artery aneurysm", section on 'Clinical presentation'.)
In general, ligation of the arteries in the groin may be tolerated if ligation is limited to a single vessel (common femoral artery, superficial femoral artery, or deep femoral artery) and provided that collateral flow is adequate (figure 1) [226,227]. Lower extremity ischemia is more likely if the femoral bifurcation needs to be excised completely.
Options for surgical revascularization of the lower extremity include interposition graft (autogenous graft) [228,229], obturator bypass (autogenous or prosthetic graft), lateral femoral bypass (autogenous or prosthetic graft), and axillary to distal femoral bypass (prosthetic graft). Although prosthetic graft material may be needed for extraanatomic reconstruction, it should be avoided in the patient with a history of active intravenous drug use [161,230-237]. (See "Lower extremity surgical bypass techniques".)
As with infected aortic aneurysms, exclusion of infected popliteal aneurysm has been managed with endovascular stenting [238,239]. (See 'Role of endovascular techniques' above.)
Amputation following management of infected femoral artery pseudoaneurysm is required in 11 to 25 percent of patients. The amputation rate in patients with intravenous drug abuse is higher at approximately 30 percent.
Visceral arteries — Mycotic aneurysms of the visceral vessels most commonly involve the superior mesenteric artery [240]. Infected aneurysms of the splenic and renal artery have also been described [182,241]. The clinical presentation of symptomatic visceral aneurysm is abdominal pain, which can be due to aneurysm rupture.
Aneurysm ligation and excision is the preferred treatment provided intestinal ischemia does not develop [134,242]. The management of visceral artery aneurysms is discussed in detail elsewhere. (See "Overview of visceral artery aneurysm and pseudoaneurysm" and "Treatment of visceral artery aneurysm and pseudoaneurysm".)
Upper extremity — In the upper extremity, the brachial artery is the most commonly affected site primarily due to intravenous drug abuse [243]. These superficial aneurysms are usually readily apparent clinically. Subclavian aneurysms can compress the surrounding neurovascular structures leading to symptoms of venous thrombosis or brachial plexopathy [120]. (See "Overview of aneurysmal disease of the aortic arch branches or upper extremity arteries in adults".)
Upper extremity vessels, including the subclavian and brachial vessels, often tolerate ligation without ischemic consequences owing to the low metabolic rate of the upper extremity musculature and collateral circulation around the shoulder (figure 2) and elbow.
SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Intestinal ischemia".)
SUMMARY AND RECOMMENDATIONS
●An infected aneurysm is a localized dilation of an artery due to destruction of the vessel wall by infection. An infected aneurysm can develop when infection of the arterial wall causes development of a new aneurysm or when a pre-existing aneurysm becomes secondarily infected. (See 'Etiology' above.)
●The organisms with the greatest affinity for the arterial wall and more likely to cause infected aneurysm are Staphylococcus spp and Salmonella spp. Other organisms include Streptococcus pneumoniae, Treponema pallidum, and Mycobacterium tuberculosis, as well as other bacterial, fungal, or anaerobic pathogens. (See 'Microbiology' above.)
●Infected aneurysms can occur in any artery but are most commonly seen in the cerebral, visceral and extremity circulations often at points of vessel bifurcation. Risk factors for infected aneurysm include trauma, endocarditis, impaired immunity, and advanced age. (See 'Risk factors' above.)
●The clinical manifestations depend upon the site of the aneurysm. The classic presentation is a painful, pulsatile, and enlarging mass together with systemic features of infection, such as fever and malaise. The mass may be palpable or demonstrable only by imaging. In the setting of aneurysm involving the aorta, the patients may complain of back or abdominal pain. Infected aneurysms can rupture, presenting as expanding hematoma or, if an intracerebral vessel is affected, as stroke or subarachnoid hemorrhage. (See 'Clinical manifestations' above.)
●The diagnosis of an infected aneurysm is based upon imaging the aneurysm and infection is confirmed by culturing an organism from the blood and/or from the aneurysm wall. If cultures are negative, molecular methods warrant pursuit. (See 'Cultures' above.)
●Computed tomography (CT) angiography definitively diagnoses the aneurysm and simultaneously evaluates the status of the circulation. Findings on CT angiography suggestive of infected aneurysm include the following (see 'Vascular imaging' above):
•Saccular, eccentric aneurysm or multilobulated aneurysm
•Soft tissue inflammation or mass around a vessel
•Aneurysm with intramural air or air collection around the vessel
•Perivascular fluid collection
●Prior to the availability of culture results, we favor treatment with a combination of vancomycin and an agent with activity against gram-negative organisms, especially Salmonella and enteric gram-negatives; reasonable choices include ceftriaxone, a fluoroquinolone, and piperacillin-tazobactam. Antibiotics should be tailored to culture and susceptibility results when they become available. The duration of therapy is individualized. (See 'Antibiotic therapy' above.)
●At extracranial sites in patients with an acceptable surgical risk, surgical excision of the aneurysm and wide debridement of infected tissues is the treatment of choice. Revascularization is performed, as needed, preferably using autogenous material passed through tissue planes remote from the site of infection. Patients with a high surgical risk and at some anatomic sites (eg, nonruptured intracerebral) may be best managed with antibiotic therapy alone. (See 'Management' above and 'Surgery' above.)
●For nonruptured infected true aneurysms in patients who are not at high risk for surgery, we prefer open surgical over endovascular methods as the primary mode of treatment. Endovascular stenting does not remove the infected focus of infection, and recurrent infection is frequent and associated with increased morbidity and mortality compared with primary surgical intervention. Endovascular techniques may be useful as a palliative measure for patients who refuse surgery, those with a prohibitive risk for surgery, and possibly for patients with ruptured infected aneurysm as a means to contain the rupture, thus allowing definitive treatment under more elective circumstances. (See 'Role of endovascular techniques' above.)
1 : The Gulstonian Lectures, on Malignant Endocarditis.
2 : Mycotic or infected aneurysm? Time to change the term.
3 : Mycotic aneurysm after percutaneous transluminal femoral artery angioplasty.
4 : Frequency, risk factors, and outcome for bacteremia after percutaneous transluminal coronary angioplasty.
5 : Secondary infection of a pre-existing thoracic aortic aneurysm by iatrogenic oesophageal perforation with aorta-oesophageal fistula formation.
6 : Perforation of the esophagus by a fish bone leading to an infected pseudoaneurysm of the thoracic aorta.
7 : Symptomatic axillary hematoma after ultrasound-guided infraclavicular block in a patient with undiagnosed upper extremity mycotic aneurysms.
8 : Bacteriologic and surgical determinants of survival in patients with mycotic aneurysms.
9 : Mycotic aortic aneurysms. A reappraisal.
10 : A rapidly expanding mycotic abdominal aortic aneurysm.
11 : Periodontitis and abdominal aortic aneurysms: a random association or a pathogenetic link?
12 : Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Involvement of Porphyromonas gingivalis in the development of human aortic aneurysm.
13 : Dental mycotic abdominal aneurysm.
14 : Infected aortic aneurysms: aggressive presentation, complicated early outcome, but durable results.
15 : Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritis.
16 : Occult caecal malignancy leading to mycotic abdominal aortic aneurysm rupture.
17 : Mycotic pseudoaneurysm of the superficial femoral artery in a patient with Cushing disease: case report and literature review.
18 : Mycotic pulmonary artery aneurysm due to Aspergillus infection in a patient with leukemia: case report and review of the literature.
19 : Ruptured mycotic aneurysm of the subclavian artery after irradiation. A case report.
20 : Cervical mycotic aneurysm in a patient with alcoholic cirrhosis.
21 : Mycotic aneurysm in hemodialysis.
22 : Candida arteritis: are GI endoscopic procedures a source of vascular infections?
23 : Primary aortoenteric fistula caused by an infected abdominal aortic aneurysm with Mycobacterium avium complex in an HIV patient.
24 : Human immunodeficiency virus associated intracranial aneurysms: report of three adult patients with an overview of the literature.
25 : A mycotic abdominal aortic aneurysm caused by Listeria monocytogenes in a patient with HIV infection.
26 : Fatal mycotic aneurysm caused by Pseudallescheria boydii after near drowning.
27 : The relevance of arterial wall microbiology to the treatment of prosthetic graft infections: graft infection vs. arterial infection.
28 : Infected false aneurysm caused by hematogenous dissemination of Staphylococcus aureus after the use of vaginal tampons.
29 : Incidence and significance of intra-operative bacterial cultures during abdominal aortic aneurysmectomy.
30 : Appendicitis: an unusual cause of infected abdominal aortic aneurysm.
31 : Acute cholecystitis preceding mycotic aortic pseudoaneurysm in a heart transplant recipient.
32 : Pseudomonas aeruginosa-infected infrarenal abdominal aorta pseudoaneurysm secondary to laparoscopic colorectal surgery: failure of endovascular stent graft treatment after primary open repair failed.
33 : Pseudoaneurysm of the inferior gluteal artery: an unusual complication after abdominoperineal resection for rectal cancer. Report of a case.
34 : Mycotic aneurysm of the infrarenal aorta after drainage of an infected chronic pancreatic pseudocyst: case report and review of the literature.
35 : Late presentation of a mycotic popliteal artery pseudoaneurysm in the setting of a revised total knee arthroplasty complicated by both prior infection and periprosthetic fracture: a case report.
36 : Iliac artery pseudoaneurysm rupture following excision of an infected hip prosthesis.
37 : Successful endovascular treatment of an infected external iliac pseudoaneurysm with hemorrhage at total hip arthroplasty.
38 : Mycotic aortic aneurysm following treatment of pyogenic vertebral osteomyelitis.
39 : Salmonella spondylodiscitis associated with a mycotic abdominal aortic aneurysm and paravertebral abscess.
40 : Spontaneous infective spondylitis and mycotic aneurysm: incidence, risk factors, outcome and management experience.
41 : Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.
42 : Symptomatic peripheral mycotic aneurysms due to infective endocarditis: a contemporary profile.
43 : Evolution and regression of intracranial infectious aneurysm diagnosed by brain computed tomographic angiography.
44 : Spontaneous healing of mycotic aortic aneurysms.
45 : Multiple pulmonary artery aneurysms due to infective endocarditis.
46 : Clinical utility of cerebral angiography in the preoperative assessment of endocarditis.
47 : Impact of routine cerebral CT angiography on treatment decisions in infective endocarditis.
48 : Infective endocarditis complicated by mycotic aneurysm of a coronary artery with a perforated mitral valvular aneurysm.
49 : Mycotic aneurysm. New concepts in therapy.
50 : Primary infected abdominal aortic aneurysm: surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period.
51 : Managing a Mycotic Thoracoabdominal Aneurysm: The Importance of Molecular Diagnostics.
52 : Surgical treatment of infected aortic aneurysm.
53 : New bacteriological patterns in primary infected aorto-iliac aneurysms: a single-centre experience.
54 : Bacterial diversity in aortic aneurysms determined by 16S ribosomal RNA gene analysis.
55 : Endovascular management of mycotic aortic aneurysms and associated aortoaerodigestive fistulas.
56 : Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis.
57 : Mycotic common iliac artery aneurysm complicating methicillin-resistant Staphylococcus aureus bacteremia: an unusual cause of ureteric obstruction.
58 : Fatal bacteremic mycotic aneurysm complicated by acute renal failure caused by daptomycin-nonsusceptible, vancomycin-intermediate, and methicillin-resistant Staphylococcus aureus.
59 : A mycotic aneurysm related to Salmonella Rissen infection: a case report.
60 : Surgical treatment for primary infected aneurysm of the descending thoracic aorta, abdominal aorta, and iliac arteries.
61 : Streptococcus pneumoniae, an emerging pathogen in mycotic aneurysms?
62 : Abdominal infectious aortitis caused by Streptococcus pneumoniae: a case report and literature review.
63 : Abdominal aortic aneurysm secondary to infection with Pseudomonas aeruginosa: a rare cause of mycotic aneurysm.
64 : Multi-resistant Escherichia coli and mycotic aneurysm: two case reports.
65 : Experience with infected aneurysms of the abdominal aorta.
66 : Chronic syphilitic aortic aneurysm complicated with chronic aortic dissection.
67 : Mycobacterium bovis abdominal aortic and femoral artery aneurysms following intravesical bacillus Calmette-Guérin therapy for bladder cancer.
68 : Tuberculous aneurysms of the abdominal aorta.
69 : Ruptured mycotic abdominal aortic aneurysm secondary to Mycobacterium bovis after intravesical treatment with bacillus Calmette-Guérin.
70 : Ruptured aortic aneurysm due to Mycobacterium bovis BCG with a delayed bacteriological diagnosis due to false negative result of the MPB 64 immunochromatographic assay.
71 : Endovascular treatment of multiple tuberculous mycotic aneurysm: A case report.
72 : Tuberculous mycotic aneurysm of the aorta: review of published medical and surgical experience.
73 : Abdominal aortic aneurysm and Coxiella burnetii infection: report of three cases and review of the literature.
74 : Localizing chronic Q fever: a challenging query.
75 : Mycotic splenic artery aneurysm secondary to Coxiella burnetii endocarditis.
76 : Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome.
77 : Q fever (Coxiella burnetii) causing an infected thoracoabdominal aortic aneurysm.
78 : Thoracic mycotic pseudoaneurysm from Candida albicans infection.
79 : Cryptococcal aortitis presenting as a ruptured mycotic abdominal aortic aneurysm.
80 : Mycotic aneurysm of the descending aorta due to Aspergillus species.
81 : Aortic Arch Mycotic Aneurysm Due to Scedosporium Apiospermum Reconstructed With Homografts.
82 : Report of a case of Streptococcus agalactiae mycotic aneurysm and review of the literature.
83 : Clostridium septicum aortitis: Report of two cases and review of the literature.
84 : Mycotic aneurysm of the ascending aorta following CABG.
85 : Rothia dentocariosa, endocarditis and mycotic aneurysms: case report and review of the literature.
86 : Infected ruptured popliteal artery aneurysm by Listeria monocytogenes. A case report and review of the literatures.
87 : Listeria monocytogenes as a rare cause of mycotic aortic aneurysm.
88 : General aneurysmatosis due to cheese consumption: complications of an endocarditis caused by Lactococcus cremoris.
89 : A surgical case of mycotic aneurysm with Staphylococcus lugdunensis endocarditis.
90 : Psoas abscess in patients with an infected aortic aneurysm.
91 : Campylobacter fetus-associated aneurysms: report of a case involving the popliteal artery and review of the literature.
92 : Infected aneurysms of bilateral deep femoral arteries due to Campylobacter fetus subspecies fetus.
93 : Aortoabdominal aneurysm infected by Yersinia enterocolitica serotype O:9.
94 : Abdominal aortic aneurysm infected by Yersinia pseudotuberculosis.
95 : Brucella-mediated prosthetic valve endocarditis with brachial artery mycotic aneurysm.
96 : Infected abdominal aortic aneurysm caused by Brucella abortus: a case report.
97 : Mycotic aneurysm of the descending thoracic aorta caused by Haemophilus influenzae.
98 : Conservative treatment of an early aortic graft infection due to Acinetobacter baumanii.
99 : Mycotic aneurysm due to Burkholderia pseudomallei infection: case reports and literature review.
100 : Stent-graft for recurrent melioidosis mycotic aortic aneurysm.
101 : Abdominal aortic pseudoaneurysm secondary to melioidosis.
102 : Mycotic aneurysm in Northeast Thailand: the importance of Burkholderia pseudomallei as a causative pathogen.
103 : Infected aneurysm after returning from Southeast Asia: think Burkholderia pseudomallei!
104 : Mycotic aneurysm secondary to melioidosis in China: A series of eight cases and a review of literature.
105 : Mycotic popliteal aneurysm rupture secondary to Campylobacter fetus.
106 : Mycotic abdominal aortic aneurysm caused by Campylobacter fetus: a case report and literature review.
107 : Bacteroides fragilis aortic arch pseudoaneurysm: case report with review.
108 : The antinflammatory effects of glucocorticosteroids. A brief review of the literature.
109 : Implications of Clostridium septicum in Vascular Surgery: A Case Report and Outcomes Literature Review.
110 : Inflammatory abdominal aortic aneurysms: a thirty-year review.
111 : Primary aortoenteric fistula due to septic aortitis.
112 : Massive upper gastrointestinal bleeding due to a ruptured superior mesenteric artery aneurysm duodenum fistula.
113 : Primary aortoappendicular fistula arising from an infected, chronic, contained, ruptured abdominal aortic aneurysm.
114 : Upper gastrointestinal bleeding secondary to an aberrant right subclavian artery-esophageal fistula: a case report and review of the literature.
115 : Mycotic superior mesenteric pseudoaneurysm draining into a vein.
116 : Airway stenosis associated with a mycotic pseudoaneurysm of the common carotid artery.
117 : A mycotic pulmonary artery aneurysm presenting as an endobronchial mass.
118 : Fatal pulmonary haemorrhage from a mycotic pulmonary artery aneurysm.
119 : Repetitive contained rupture of an infected abdominal aortic aneurysm with concomitant vertebral erosion.
120 : Brachial plexopathy secondary to mycotic subclavian-axillary artery aneurysm.
121 : Vascular Graft Infections, Mycotic Aneurysms, and Endovascular Infections: A Scientific Statement From the American Heart Association.
122 : Management of infected aortoiliac aneurysms.
123 : Aortitis due to Salmonella: report of 10 cases and comprehensive review of the literature.
124 : Surgical pathology of infected aortic aneurysm and its clinical correlation.
125 : Molecular diagnosis and characterization of a culture-negative mycotic aneurysm due to ST54 Haemophilus influenzae type b with PBP 3 alterations.
126 : Melioidosis presenting as a mycotic aneurysm in a Korean patient, diagnosed by 16S rRNA sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
127 : Infected aortic aneurysms: CT appearance.
128 : Mycotic aneurysm of the aorta: MRI and MRA features.
129 : Infected pulmonary artery aneurysms: CT imaging findings.
130 : Infected aortic aneurysms: CT diagnosis.
131 : Diagnostic imaging of Salmonella-related mycotic aneurysm of aorta by CT.
132 : Evolution of the infected abdominal aortic aneurysm: CT observation of early aortitis.
133 : Infected (mycotic) aneurysms: spectrum of imaging appearances and management.
134 : Clinical challenges and images in GI. Mycotic aneurysm of the superior mesenteric artery.
135 : Mycotic aneurysm of the celiac trunk: from early CT sign to rupture.
136 : Contribution to FDG-PET/CT diagnostics and post-operative monitoring of patients with mycotic aneurysm of the thoracic aorta.
137 : F-18 FDG PET-CT imaging of a mycotic aneurysm.
138 : Detection of an infected abdominal aortic aneurysm with three-phase bone scan and gallium-67 scan.
139 : F-18 FDG PET/CT in the management of infected abdominal aortic aneurysm due to Salmonella.
140 : Detection of aortic graft infection by fluorodeoxyglucose positron emission tomography: comparison with computed tomographic findings.
141 : Avid FDG uptake in a rapidly enlarging common carotid artery mycotic aneurysm, mimicking lymphadenopathy.
142 : Bone and leukocyte scintigraphy of a complicated case of ruptured mycotic aneurysm of the aorta. A case history.
143 : Fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis of infected aortic aneurysms.
144 : Endovascular treatment of mycotic aortic aneurysms: a European multicenter study.
145 : Endovascular treatment of mycotic saccular aneurysms of the thoracic aorta.
146 : Outcome after endovascular stent graft treatment for mycotic aortic aneurysm: a systematic review.
147 : Successful endoluminal repair of an infected thoracic pseudoaneurysm caused by methicillin-resistant Staphylococcus aureus.
148 : The efficacy of aortic stent grafts in the management of mycotic abdominal aortic aneurysm-institute case management with systemic literature comparison.
149 : Repair of mycotic paravisceral aneurysm with a fenestrated stent-graft.
150 : Endovascular stent-graft for thoracic aorta aneurysm caused by Salmonella.
151 : Endovascular repair of Salmonella-infected abdominal aortic aneurysms: a word of caution.
152 : Successful treatment of multiple mycotic aortic aneurysms, using a hybrid procedure.
153 : Endovascular repair of mycotic aortic aneurysms.
154 : Endovascular treatment of a tuberculous infected aneurysm of the descending thoracic aorta: a word of caution.
155 : Endovascular stent graft repair for infected thoracic aortic pseudoaneurysms--a durable option?
156 : Ruptured mycotic thoracoabdominal aortic aneurysms: a report of three cases and a systematic review.
157 : In situ prosthetic graft replacement for mycotic aneurysm of the aorta.
158 : Selective medical treatment of infected aneurysms of the aorta in high risk patients.
159 : Treatment options for primary infected aorta.
160 : Spontaneous abdominal aortic infections. Essentials of diagnosis and management.
161 : Implantation of antibiotic-releasing carriers and in situ reconstruction for treatment of mycotic aneurysm.
162 : In situ arterial allografting for aortoiliac graft infection: a 6-year experience.
163 : Mycotic aneurysm of the aorta: evolving surgical concept.
164 : In situ repair of mycotic aneurysm of the ascending aorta.
165 : The infected aorta.
166 : In situ versus extra-anatomic reconstruction for primary infected infrarenal abdominal aortic aneurysms.
167 : Use of rifampin-soaked gelatin-sealed polyester grafts for in situ treatment of primary aortic and vascular prosthetic infections.
168 : Superficial femoral vein graft interposition in situ repair for femoral mycotic aneurysm.
169 : Arterial reconstruction with deep leg veins for the treatment of mycotic aneurysms.
170 : Technical details with the use of cryopreserved arterial allografts for aortic infection: influence on early and midterm mortality.
171 : Abdominal aortic reconstruction in infected fields: early results of the United States cryopreserved aortic allograft registry.
172 : Infected abdominal aortic aneurysm treated by in situ replacement with cryopreserved arterial homograft.
173 : Eight-year experience with cryopreserved arterial homografts for the in situ reconstruction of abdominal aortic infections.
174 : Arterial reconstruction with cryopreserved human allografts in the setting of infection: A single-center experience with midterm follow-up.
175 : Arterial infections in the new millenium: an old problem revisited.
176 : The sartorius muscle flap: an important adjunct for complicated femoral wounds involving vascular grafts.
177 : Palliative stent-graft insertion followed by an allograft replacement for an infected and ruptured aortic aneurysm.
178 : Endovascular repair of a ruptured mycotic aneurysm of the common iliac artery.
179 : Emergency stenting of a ruptured infected anastomotic femoral pseudoaneurysm.
180 : Emergency endovascular treatment of early spontaneous nonaneurysmal popliteal artery rupture in a patient with Salmonella bacteremia.
181 : Hybrid repair of ruptured infected anastomotic femoral pseudoaneurysms: Emergent stent-graft implantation and secondary surgical debridement.
182 : Images in cardiovascular medicine. Rupture of infected splenic artery aneurysm secondary to infective endocarditis.
183 : Endovascular stent graft placement in the treatment of ruptured tuberculous pseudoaneurysm of the descending thoracic aorta: case report and review of the literature.
184 : Coil occlusion of a subclavian mycotic aneurysm.
185 : Endovascular management of a ruptured mycotic aneurysm of the innominate artery.
186 : Late outcomes of endovascular aortic repair for the infected thoracic aorta.
187 : Endoluminal repair of mycotic thoracic aneurysms.
188 : Thoracic aortic endovascular repair for mycotic aneurysms and fistulas.
189 : Endovascular management of a descending thoracic mycotic aneurysm: mid-term follow-up.
190 : Endoluminal stenting of thoracic aorta mycotic aneurysms.
191 : Stent-graft treatment of mycotic aneurysms: a review of the current literature.
192 : Endovascular repair in the presence of aortic infection.
193 : Nationwide Study of the Treatment of Mycotic Abdominal Aortic Aneurysms Comparing Open and Endovascular Repair.
194 : Neurological manifestations of infective endocarditis. Review of clinical and therapeutic challenges.
195 : Interdisciplinary Treatment of Intracranial Infectious Aneurysms.
196 : A dangerous dilemma: management of infectious intracranial aneurysms complicating endocarditis.
197 : Intracranial infectious aneurysms: a comprehensive review.
198 : Treatment of a bacterial (mycotic) intracranial aneurysm using an endovascular approach.
199 : Endovascular treatment for bilateral mycotic intracavernous carotid aneurysms. Case report and review of the literature.
200 : Endovascular management of ruptured cerebral mycotic aneurysms.
201 : Systematic Review of Endovascular, Surgical, and Conservative Options for Infectious Intracranial Aneurysms and Cardiac Considerations.
202 : Infectious thoracic aortitis: a literature review.
203 : Multiple infected aortic aneurysms repaired by staged in situ graft replacement.
204 : The treatment of infectious aneurysms in the thoracic aorta; our experience in treating five consecutive patients.
205 : Infected aneurysm of the thoracic aorta.
206 : Surgery for infected aneurysm of the aortic arch.
207 : Successful in situ treatment of infected aortic arch prosthesis by omental wrapping.
208 : Graft replacement and muscle wrap for infected aneurysm of thoracic aorta.
209 : Single-center experience with open surgical treatment of 36 infected aneurysms of the thoracic, thoracoabdominal, and abdominal aorta.
210 : Diagnosis and management of mycotic aneurysms.
211 : Diagnosis and management of aortic mycotic aneurysms.
212 : Treatment of mycotic aneurysms with involvement of the abdominal aorta: single-centre experience in 44 consecutive cases.
213 : Extra-anatomic revascularization and aortic exclusion for mycotic aneurysms of the infrarenal aorta and iliac arteries in an Asian population.
214 : Long-term results of the treatment of aortic graft infection by in situ replacement with femoral popliteal vein grafts.
215 : Primary infected, ruptured abdominal aortic aneurysms: what we learned in 10 years.
216 : Mycotic aneurysms of the suprarenal abdominal aorta: prolonged survival after in situ aortic and visceral reconstruction.
217 : Cryptogenic Salmonella-infected ruptured aortic aneurysms.
218 : Mycotic aneurysms of the carotid artery: ligation vs. reconstruction--case report and review of the literature.
219 : Management of extracranial carotid artery aneurysms: 17 years' experience.
220 : Extracranial internal carotid artery mycotic aneurysm: case report and review.
221 : Mycotic carotid pseudoaneurysm: staged endovascular and surgical repair.
222 : Extracranial infected carotid artery aneurysm.
223 : Superficial Femoral Artery Interposition Graft for Repair of a Ruptured Mycotic Common Carotid Artery Pseudoaneurysm: Case Report and Review of the Literature.
224 : Open surgical ligation of a symptomatic mycotic aneurysm of the peroneal artery.
225 : Large mycotic aneurysm of the peroneal artery.
226 : Tolerable hemodynamic changes after femoral artery ligation for the treatment of infected femoral artery pseudoaneurysm.
227 : Femoral artery ligation as treatment for infected pseudo-aneurysms, secondary to drug injection.
228 : A 10-year experience of using femoro-popliteal vein for re-vascularisation in graft and arterial infections.
229 : Femoral bifurcation infected pseudoaneurysm: a simple and quick arterial reconstruction with reversed bifurcated saphenous vein graft.
230 : Management of septic groin complications and infected femoral false aneurysms in intravenous drug abusers.
231 : Management of infected femoral pseudoaneurysms in intravenous drug abusers: a review of 57 cases.
232 : Arterial consequences of recreational drug use.
233 : Surgical management of infected pseudoaneurysms in intravenous drug abusers: single institution experience and a proposed algorithm.
234 : On the management of mycotic femoral pseudoaneurysms in intravenous drug abusers.
235 : The management of mycotic femoral pseudoaneurysms in intravenous drug abusers.
236 : Surgical approach to vascular complications of intravenous drug abuse.
237 : Infected femoral artery pseudoaneurysm in drug addicts: the beneficial use of the internal iliac artery for arterial reconstruction.
238 : Endovascular repair of a ruptured, mycotic popliteal aneurysm.
239 : Surgical treatment of an infected popliteal artery aneurysm 12 years after aneurysm exclusion and bypass.
240 : Mycotic superior mesenteric aneurysm.
241 : Infected splenic artery aneurysm with associated splenic abscess formation secondary to bacterial endocarditis: case report and review of the literature.
242 : Open and endovascular treatment for pseudoaneurysms of the superior mesenteric artery.
243 : Infected upper extremity aneurysms: a review.